Regulation and Function of LINE-1 Retrotransposons in Development and Disease
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What is LINE-1 or L1? Long interspersed elements (LINEs) are common components of mammalian genomes. The human genome contains over 500,000 LINE-1 (L1) copies, most of which are 5' truncated. It is estimated that up to 100 L1s are active in the average diploid human genome, whereas ~3000 are potentially active in a diploid mouse genome. Read on to learn more about these fascinating elements.
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