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An Lab Publications

The Laboratory of Wenfeng An

Recent Publications

Ray DA, Paulat N, An W, Boissinot S, Cordaux R, Kaul T, Freeman B, Belancio V. The 2019 FASEB Science Research Conference on The Mobile DNA Conference: 25 Years of Discussion and Research, June 23–28, Palm Springs, California, USA. FASEB Journal, 33(11):11625-11628 (2019). PMID: 31671501. DOI: 10.1096/fj.201902390

Vazquez, B.N., Thackray, J.K., Simonet, N., Chahar, S., Kane-Goldsmith, N., Newkirk, S.J., Lee, S., Xing, J., Verzi, M.P., An, W., Vaquero, A., Tischfield, J.A., and Serrano, L. SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic Acids Research, 47:7870–7885 (2019). PMID: 31226208. DOI: 10.1093/nar/gkz519

Wang, Z., McSwiggin, H., Newkirk, S.J., Wang, Y., Oliver, D., Tang, C., Lee, S., Wang, S., Yuan, S., Zheng, H., Ye, P., An, W., Yan, W. Insertion of a chimeric retrotransposon sequence in mouse Axin1 locus causes metastable kinky tail phenotype. Mobile DNA, 10:17 (2019). PMID: 31073336. PMCID: PMC6500023. DOI: 10.1186/s13100-019-0162-7

Saha, P., An, W. Recently Mobilized Transposons in the Human Genome. In: eLS. John Wiley & Sons Ltd, Chichester. (2019). DOI: 10.1002/9780470015902.a0020837 (PDF available)

Boris Reznik, Steven A. Cincotta, Rebecca G. Jaszczak, Leslie J. Mateo, Joel Shen, Mei Cao, Laurence Baskin, Ping Ye, Wenfeng An, Diana J. Laird. Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells. Development 146(12):dev171157 (2019). PMID: 30658985. PMCID: PMC6602354. DOI: 10.1242/dev.171157

Kawano, K., Doucet, A.J., Ueno, M., Kariya, R., An, W., Marzetta, F., Kuroki, M., Turelli, P., Sukegawa, S., Okada, S., Strebel, K., Trono, D., Ariumi, Y. HIV-1 Vpr and p21 restrict LINE-1 mobility. Nucleic Acids Research 46:8454–8470 (2018). PMID: 30085096. PMCID: PMC6144823. DOI: 10.1093/nar/gky688

Sheng, Z., Liu, R., Yu, J., Ran, Z., Newkirk, S.J., An, W., Li, F. & Wang, D. Identification and characterization of viral defective RNA genomes in influenza B virus. Journal of General Virology 99(4):475-488 (2018). PMID: 29458654. PMCID: PMC5982128. DOI: 10.1099/jgv.0.001018

Newkirk, S.J., Lee, S., Grandi, F.C., Gaysinskaya, V., Rosser, J.M., Vanden Berg, N., Hogarth, C.A., Marchetto, M.C.N., Muotri, A.R., Griswold, M.D., Ye, P., Bortvin, A., Gage, F.H., Boeke, J.D. & An, W. Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A 114:E5635–E5644 (2017). PMID: 28630288. PMCID: PMC5514719. DOI: 10.1073/pnas.1701069114. Commented by: Wang, P.J. Tracking LINE1 retrotransposition in the germline. Proc Natl Acad Sci U S A 114:7194–7196 (2017). Highlighted by: Chen, C. A novel reporter mouse to monitor in vivo retrotransposition in the germline. Biology of Reproduction 97:335-336 (2017)

Kannan, M., Li, J., Fritz, S.E., Husarek, K.E., Sanford, J.C., Sullivan, T.L., Tiwary, P.K., An, W., Boeke, J.D. & Symer, E.E. Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration. Mobile DNA 8:8 (2017). PMID: 28491150. PMCID: PMC5424313. DOI: 10.1186/s13100-017-0091-2.

Newkirk, S.J. & An, W. L1 Regulation in Mouse and Human Germ Cells. in Human Retrotransposons in Health and Disease, ed Cristofari G (Springer International Publishing), pp 29-61 (2017). 

Kharytonchyk, S., King, S.R., Ndongmo, C.B., Stilger, K.L., An, W., & Telesnitsky, A. Resolution of Specific Nucleotide Mismatches by Wild-Type and AZT-Resistant Reverse Transcriptases during HIV-1 Replication. Journal of Molecular Biology. 428:2275–2288 (2016). PMID: 27075671. PMCID: PMC4884515. DOI: 10.1016/j.jmb.2016.04.005.

Grandi, F.C., Rosser, J.M., Newkirk, S.J., Yin, J., Jiang, X., Xing, Z., Whitmore, L., Bashir, S., Ivics, Z., Izsvák, Z., Ye, P., Yu, Y.E. & An, W. Retrotransposition creates sloping shores: a graded influence of hypomethylated CpG islands on flanking CpG sites. Genome Research. 25:1135-1146 (2015). PMID: 25995269. PMCID: PMC4509998. DOI: 10.1101/gr.185132.114.

Grandi, F.C. & An, W. Non-LTR retrotransposons and microsatellites: Partners in genomic variation. Mobile Genetic Elements. 3:e25674 (2013). PMID: 24195012. PMCID: PMC3812793. DOI: 10.4161/mge.25674.

O'Donnell, K.A., An, W., Schrum, C.T., Wheelan, S.J., & Boeke, J.D. Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model. Proc Natl Acad Sci U S A 110:E2706-13 (2013). PMID: 23818630. PMCID: PMC3718180. DOI: 10.1073/pnas.1302504110.

Xie, Y., Mates, L., Ivics, Z., Izsvák, Z., Martin, S.L. & An, W. Cell division promotes efficient retrotransposition in a stable L1 reporter cell line. Mobile DNA. 4:10 (2013). PMID: 23497436. PMCID: PMC3607998. DOI: 10.1186/1759-8753-4-10.

Grandi, F.C., Rosser, J.M. & An, W. LINE-1 derived poly(A) microsatellites undergo rapid shortening and create somatic and germline mosaicism in mice. Molecular Biology and Evolution. 30:503-12 (2013). PMID: 23125228. PMCID: PMC3563966. DOI: 10.1093/molbev/mss251.

Ray, D., Hogarth, C.A., Evans, E.B., An, W., Griswold, M.D., & Ye, P. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Biology of Reproduction 86(4):102 (2012). PMID: 22190705. PMCID: PMC4480071. DOI: 10.1095/biolreprod.111.095216.

Rosser, J.M. & An, W. L1 expression and regulation in humans and rodents. Frontiers in Bioscience E4:2203-25 (2012). PMID: 22202032. PMCID: PMC4457320

An, W., Dai, L., Niewiadomska, A.M., Yetil, A., O'Donnell, K.A., Han, J.S., & Boeke, J.D. Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs. Mobile DNA. 2:2 (2011). PMID: 21320307. PMCID: PMC3045867. DOI: 10.1186/1759-8753-2-2.

Xie, Y., Rosser, J.M., Thompson, T.L., Boeke, J.D. & An, W. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays. Nucleic Acids Research 39, e16 (2011). PMID: 21320307. PMCID: PMC3045867. DOI: 10.1093/nar/gkq1076.

Rosser, J.M. & An, W. Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation. Gene 456, 15-23 (2010). PMID: 20167267. PMCID: PMC3001326. DOI: 10.1016/j.gene.2010.02.005.

An, W., Davis, E.S., Thompson, T.L., O'Donnell, K.A., Lee, C.-Y. & Boeke, J.D. Plug and play modular strategies for synthetic retrotransposons. Methods 49, 227-35 (2009). PMID: 19481606. PMCID: PMC2763960. DOI: 10.1016/j.ymeth.2009.05.013.

Han, Y., Lin, Y.B., An, W., Xu, J., Yang, H.C., O'Connell, K., Dordai, D., Boeke, J.D., Siliciano, J.D., & Siliciano, R.F. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4, 134-46 (2008). PMID: 18692773. PMCID: PMC2604135. DOI: 10.1016/j.chom.2008.06.008.

An, W., Han, J.S.,Schrum, C.M., Maitra, A., Koentgen, F. & Boeke, J.D. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46, 373-83 (2008). PMID: 18615728. PMCID: PMC2614868. DOI: 10.1002/dvg.20407.

Boeke, J.D., An, W., Dai, L., Davis, E.S, Han, J.S., O'Donnell, K.A., Scheifele, L.Z. & Wheelan, S.J. Retrotransposons-natural and synthetic. in Retrotransposition, Diversity and the Brain (eds. Gage, F.H. & Christen, Y.) 21-32 (Springer, 2008). doi:10.1007/978-3-540-74966-0_3. ISBN: 978-3-540-74965-3 (Print) 978-3-540-74966-0 (Online)

An, W., Han, J.S., Wheelan, S.J., Davis, E.S., Coombes, C.E., Ye, P., Triplett, C. & Boeke, J.D. Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A 103, 18662-7 (2006). PMID: 17124176. PMCID: PMC1693719. DOI: 10.1073/pnas.0605300103.

An, W. & Boeke, J.D. Transposon technology and vertebrate functional genomics. Genome Biology 6, 361 (2005). PMID: 16356279. PMCID: PMC1414074. DOI: 10.1186/gb-2005-6-12-361.