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T-00329: Amino acid derivatives of anticancer drugs (AT-Platin)

Background: The main drawbacks of cisplatin treatment are its dose dependent side effects. The side effects of cisplatin chemotherapy include general cell damaging effects such as nausea and vomiting, bone marrow suppression, immunosuppression, acute kidney damage, and hearing loss.

Description: SDSU researchers have developed a novel platinum based drug that is more efficient than cisplatin and less toxic. The drug design is uses novel derivatives of anti-cancer drugs by conjugating with an amino acid.

Advantages: The synthesized derivatives have the potential to increase the specificity to cancer cells through nutrition transporters. They may also lower systemic toxicity, improve the quality of life of the patient and reduce health care costs, and have simple synthetic procedures and scale-up.