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Shafiqur Rahman

Photo of Shafiqur Rahman
Title Professor
Office Building Avera Health & Science Center
Room Number 265
Mailing Address South Dakota State University
Pharmacy & Allied Health Professions
SAV 265, Box 2202C
Brookings, SD 57007

Professional Memberships

Society for Neuroscience (SFN)
American Society for Pharmacology and Experimental Therapeutics (ASPET)
American Association of Colleges of Pharmacy (AACP)
American Association of Pharmaceutical Scientists (AAPS)
International Brain Research Organization (IBRO)
Novel Global Community Educational Foundation (NGCEF)
Rho Chi Pharmacy Honor Society
Sigma Xi Scientific Research Society

Regional Editor, CNS Neurological Disorders-Drug Targets (2016-present)
Editor, Molecular Basis of Drug Addiction/Progress in Molecular Biology and Transnational Science (2015-2016)
Editor, Animal Models for Medications Screening to Treat Addiction/International Review of Neurobiology (2016-2017)
Editor, Brain as a Drug Target/Progress in Molecular Biology and Transnational Science (2010-2011)
Editor, Drug Addiction and Brain Targets from Preclinical Research to Pharmacotherapy (2008-2009)
Editorial Board Member for Journals (2008-present):
International Review of Neurobiology
Journal of Addiction Research and Therapy
Current Drug Abuse Review
Drug Discoveries and Therapeutics
Frontiers Journals in Neuropharmacology
CNS Neurological Disorders-Drug Targets
Aging and Neurodegeneration
Invited Speaker, Target Discovery World Congress, San Francisco, USA (2008)
Reviewer for >25 Scientific Journals in the field of research expertise
Evaluator, Accreditation Council for Pharmacy Education (ACPE) (2017)
Co-Chair, Teaching Institute for Graduate Pharmacology Education, American Society for
Pharmacology and Experimental Therapeutics (ASPET) at the Experimental Biology Meeting in San Diego (2018)
Secretary/Treasurer, American Society for Pharmacology and Experimental Therapeutics (ASPET)-Division of Pharmacology Education (2018-2020)

Academic Interests/Expertise

Pharmacology; Neuropharmacology; Drug Addiction; Therapeutic Drug Discovery for Neuroropsychiatric and Neurological Disease; Mental Illness; Pharmaceutical Education; Higher Education; Public Health and Policy Issues;

Area(s) of Research

Medication development for drug addiction and CNS disorders
Drug discovery for neuropsychiatric disorders
Drug discovery for neuroinflammatory and neuropathic pain
Mental illness and substance abuse research for public health

*Corresponding Author/Mentor

Rahman S, Bell RL. Nicotinic cholinergic mechanisms in alcohol abuse and dependence. Neuroscience of Alcohol, Elsevier Inc, in press (2018).

Alzarea S, Rahman S*. Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice. Progress in Neuropsychopharmacology & Biological Psychiatry, 86, 218-228 (2018).

Roni MA, Rahman S*. Lobeline attenuates ethanol withdrawal-induced depression-like behavior in mice. Alcohol 61, 63-70 (2017).

Abbas M, Alzarea S, Papke RL, Rahman S*. The α7 nicotinic acetylcholine receptor positive allosteric modulator Attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice. Drug Discoveries & Therapeutics 11, 206-211 (2017).

Islam N, Abbas M, Rahman S*. Neuropathic pain and lung delivery of nanoparticulate drugs: an emerging novel therapeutic strategy. CNS Neurological Disorders Drug Targets 16, 303-310 (2017).

Abbas M, Rahman S*. Effects of alpha-7 nicotinic acetylcholine receptor positive allosteric modulator on lipopolysachharide-induced neuroinflammatory pain in mice. European Journal of Pharmacology 783, 85-91 (2016).

Bell RL, Hauser S, Rodd ZA, Liang T, Sari Y, McClintick J, Rahman S, Engleman EA. A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. International Review of Neurobiology 126, 179-260 (2016).

Rahman S*, Engleman EA, Bell RL. Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism. Progress Molecular Biology and Transnational Science 137,183-201 (2016).

Bell RL, Hauser SR, McClintick J, Rahman S, Edenberg HJ, Szumlinski KK, McBride WJ. Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. Progress in Molecular Biology Transnational Science 137, 41-85 (2016).

Sajja RK, Rahman S, Cucullo L. Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress. Journal of Cerebral Blood Flow and Metabolism, 36, 539-554 (2016).

Roni MA, Rahman S*. Effects of lobeline and reboxetine, fluoxetine, or bupropion combination on depression-like behaviors in mice. Pharmacology Biochemistry Behavior 139, 1-6 (2015).

Rahman S*, Engleman EA, Bell RL. Nicotinic receptor modulation to treat alcohol and drug dependence. Frontiers in Neuroscience-Neuropharmacology 8, (426), 1-11 (2015).

Roni MA, Rahman S*. The effects of lobeline on depression-like behavior and hippocampal dell proliferation following chronic unpredictable stress in mice. Neuroscience Letters 584, 7-11 (2015).

Roni MA, Rahman S*. The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice. Psychopharmacology 231, 2989-2998 (2014).

Sajja RK, Rahman S*. Nicotinic receptor partial agonists modulate alcohol deprivation effect in C57BL/6J in mice. Pharmacology Biochemistry and Behavior 110, 161-167 (2013).

Rahman S*. Nicotinic Receptors as Therapeutic Targets for Drug Addictive Disorders. CNS & Neurological Disorders-Drug Targets 12, 633-640 (2013).

Sajja RK, Rahman S*. Cytisine modulates chronic voluntary ethanol consumption and ethanol-induced striatal up-regulation of Delta FosB in mice. Alcohol 47, 299-307 (2013).

Roni MA, Rahman S*. Antidepressant-like effects of lobeline in mice: behavioral, neurochemical and neuroendocrine evidence. Progress in Neuropsychopharmacology and Biological Psychiatry 41, 44-51 (2013).

Rahman S*, Prendergast MA. Brain cholinergic receptor system as a target for treating alcohol dependence. Recent Patents on CNS Drug Discovery 7, 145-150 (2012).

Sajja RK, Rahman S*. Nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice. Pharmacology, Biochemistry and Behavior 102, 36-43 (2012).

Islam N, Rahman S*. Improved treatment of nicotine addiction and pulmonary drug delivery. Drug Discovery and Therapeutics, 6, 123-132 (2012).

Roni MA, Rahman S*. Neuronal nicotinic receptor ligand lobeline reduces anxiety-like behavior in mice. Neuroscience Letters 504, 237-241 (2011).

Sajja RK, Rahman S*. Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice. Progress in Neuropsychopharmacology and Biological Psychiatry 35, 257-264 (2011).

Rahman S*. Brain nicotinic receptors as emerging targets for drug addiction: neurobiology to transnational science. Progress in Molecular Biology Transnational Science 98, 349-365 (2011).

Sajja RK, Dwivedi, C, Rahman S*. Nicotinic ligands modulate ethanol-induced dopamine function in mice. Pharmacology 86,168-73 (2010).

Meyer AC, Rahman S, Charnigo RJ, Dwoskin LP, Crabbe JC, Bardo MT. Genetics of novelty seeking, amphetamine self-administration and reinstatement using inbred rats. Genes, Brain and Behavior 9, 790-798 (2010).

Rahman S*. Targeting opioid receptors treatment for brain disorders. CNS & Neurological Disorders-Drug Targets 9, 128 (2010).

Hasan SMR, Hossain, MM, Akter R, Jamila, M, Mazumder MEH, Alam MA, Faruque, A, Rana S, Rahman S*. Analgesic activity of the different fractions of the aerial parts of Commelina benghalensis Linn. International Journal of Pharmacology 6, 63-67 (2010).

Bell RL, Eilier BA, Cook, JB, Rahman S*. Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats. Alcohol 43, 581-592 (2009).

Hasan R. S.M., Jamila, M, Majumder MM, Akter R., Hossain MM., Mazumder MEH, Alam, MA, Jahangir R, Rana, MS, Arif M. and Rahman S*. Analgesic and antioxidant activity of the Hydromethanolic extract of Mikania scandens (L.) Willd. Leaves. American Journal of Pharmacology Toxicology 4, 1-7 (2009).

Hasan, SMR, Hossain, MM, Akter R, Jamila, M, Mazumder MEH, Faruque A, Rahman S*. Sedative and anxiolytic effects of different fractions of Commelina benghalensis. Drug Discoveries & Therapeutics 3, 221-227 (2009).

Hasan SMR, Hossain, MM, Akter R, Jamila, M, Mazumder MEH, Rahman, S*. DPPH free radical scavenging activity of some Bangladeshi medicinal plants. Journal of Medicinal Plants Research, 3, 875-879 (2009).

Rahman S*. Drug Addiction and Brain Targets: from Preclinical research to Pharmacotherapy. CNS & Neurological Disorders-Drug Targets 7, 391-392 (2008).

Rahman S*, Lopez-Hernandez G, Corrigall WA., Papke RL, Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction. CNS and Neurological Disorders-Drug Targets 7, 422-441 (2008).

Rahman S, Neugebauer NM., Zhang Z, Crooks PA, Dwoskin LP, Bardo MT, The novel nicotinic receptor antagonist N,N’-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens. European Journal of Pharmacology 601, 103-105 (2008).

Rahman S, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. Region-specific effects of N,N’-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on nicotine-induced increase in extracellular dopamine in vivo. British Journal of Pharmacology 153, 792–804 (2008).

Rahman S, Bardo MT. Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: a neurochemical study. Brain Research 1197, 40-46 (2008).

Islam N, Rahman S*, Pulmonary drug delivery: Implication for new strategy for pharmacotherapy of neurodegenerative disorders. Dug Discoveries & Therapeutics 5, 264-276 (2008).

Mazumder MEH, Rahman S*. Pharmacological evaluation of Bangladeshi Medicinal Plants for antioxidant activity. Pharmaceutical Biology 46, 704-709 (2008)

Rahman S, Neugebauer NM, Zhang Z, Crooks PA, Dwoskin LP, Bardo MT. The effects of novel N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide on acute and repeated nicotine-induced increases in extracellular dopamine response in rat nucleus accumbens. Neuropharmacology 52, 755-763 (2007).

Rahman S*, Zhang J., Engleman E, Corrigall WA. Neuroadaptive changes in mesolimbic dopamine system after chronic nicotine self-administration: A microdialysis study. Neuroscience 129, 415-424 (2004).

Rahman S*, Zhang J, Corrigall WA. Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine pre-exposure. Neurochemical Research 29, 1687-1693 (2004).

Rahman S*, Zhang J, Corrigall WA. Effect of nicotine exposure on sulpiride-induced dopamine release in the nucleus accumbens. European Journal Pharmacology 494, 31-34 (2004).

Rahman S*, Zhang J, Corrigall, WA. Effects of acute and chronic nicotine on somatodendritic dopamine release of the rat ventral tegmental area in vivo microdialysis study. Neuroscience Letters 348, 61-64 (2003).

Rahman S, McBride WJ. Involvement of GABA and cholinergic receptors in the nucleus accumbens on feedback control of somatodendritic dopamine release in the VTA. Journal of Neurochemistry 80, 646-654 (2002).

Rahman S and McBride WJ. Dopamine D1-D2 receptor interaction within the nucleus accumbens mediates long-loop negative feedback to the VTA. Journal of Neurochemistry 77, 1248-1255 (2001).

Rahman S, Engleman E, Simon J, and McBride WJ. Negative interaction of D2 receptor antagonist and GBR-12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. European Journal Pharmacology 414, 37-44 (2001).

Rahman S*, Hasnat A, Hasan CM, Rashid MA and Ilias M. Pharmacological Evaluation of traditionally used medicinal plants of Bangladesh. Pharmaceutical Biology 39, 1-6 (2001).

Rahman S, McBride WJ. Feedback control of mesolimbic somatodendritic dopamine release in rat brain. Journal of Neurochemistry 74, 684-692 (2000).

Rahman S, Li, PP, Kish SJ, Young LT, Kofman O, Warsh JJ. Reduced [3H]cAMP binding in bipolar affective disorder. Journal of Neurochemistry 68, 297-304 (1997).

Kofman O, Rahman S, Li PP, Warsh JJ. Lithium and carbamazepine differentially affect locomotion and cAMP binding stimulated by cholera toxin. Biological Psychiatry, 39, 594-595 (1996)

Rahman S, Li PP, Kish SJ, Young LT, Warsh JJ. Decreased [3H] cAMP binding in postmortem brain in bipolar disorder. Biological Psychiatry, 39, 583-584 (1996)

Rahman S and Neuman RS. Calcimycin, cyclopiazonic acid and Thapsigargin mimic 5-hydroxytryptamine in facilitating N-methyl-D-aspartate depolarization of cortical neurons. British Journal of Pharmacology 119, 877-884 (1996)

Rahman S, Neuman RS. Characterization of metabotropic glutamate receptor mediated facilitation of N-methyl-D-aspartate depolarization of neocortical neurons. British Journal of Pharmacology 117, 675-683 (1996).

Rahman S, McLean J, Darby-King A, Paterno G, Reynolds J, Neuman RS. Loss of cortical serotonin 5-HT2A signal transduction in senescent rats: reversal following inhibition of protein kinase C. Neuroscience 66, 891-901 (1995).

Neuman RS, Rahman S. Calcium mobilizing compounds mimic 5-HT Induced facilitation of N-methyl-D-aspartate depolarization. Behavioral Brain Research 73, 273-275 (1995).

Rahman S, Neuman RS. Multiple mechanisms of serotonin (5-HT2A) Receptor desensitization. European Journal of Pharmacology 238, 173-180 (1993).

Rahman S, Neuman RS. Myo-inositol reduces serotonin (5-HT2A) Receptor induced homologous and heterologous desensitization. Brain Research 631, 349-351 (1993).

Rahman S, Neuman RS. Activation of 5-HT2A receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate. European Journal of Pharmacology 231, 347-354 (1993).

Over 145 Abstracts or Presentations from regional/national and international meetings/conferences or seminars/symposiums.

Over 40 invited presentations/seminars at numerous Academic Institutions and Professional Meetings in the USA, Canada and overseas.

Academic Responsibilities

Pharmacology I (PHA 442)
Pharmacology II (PHA 443)
Drugs of Abuse and Addiction (PHA 752)
Integrated Pathophysiol-Pharmacol-Toxicol (PHA 352)
Advanced Concepts in Pharmacology (PHA 840)
Topics in Pharmaceutical Sciences (PHA 825)
Topics in Advanced Pharmacology (PHA 845)
Techniques in Pharmaceutical Sciences (PHA 846)
Seminar in Pharmaceutical Sciences (PHA 890)
Introduction to Pharmaceutical Sciences (PHA 720)
Medications and Wellness (PHA 201)


Fulbright Foundation, USA
Saudi Arabia Cultural Mission (SACM), Washington DC, USA
NIH/National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH/National Institute on Drug Abuse (NIDA)
American Foundation for Pharmaceutical Education (AFPE)
American Association of Colleges of Pharmacy (AACP)
Addiction Research Foundation
Avera Research Institute/Avera Research Foundation
South Dakota Research & Development Innovation Grant/South Dakota Board of Regents
South Dakota State University (SDSU) Research Foundation
SDSU Academic Excellence Fund
SDSU Research Support Fund
SDSU Juhnke Endowment Fund
South Dakota Governor's 2010 Research Initiative Fund
University of Kentucky Research Foundation
Clark Foundation, University of Toronto, Canada
Canadian Institutes of Health Research

Awards & Honors

Community Engagement Award, College of Pharmacy, South Dakota State University (2018)
Academic Leadership Fellow, American Association of Colleges of Pharmacy (2015-2016)
Distinguished Service Award, National Association on Mental Illness-South Dakota Chapter (2014)
TRiO Students’ Choice Award for Teaching, South Dakota State University (2013)
Distinguished Scholar and Researcher, College of Pharmacy, South Dakota State University (2010)
Fellow, American Foundation for Pharmaceutical Education (2008)
Clarke Foundation Postdoctoral Fellowship, University of Toronto, Canada (1995)
Fellow, School of Graduate Studies, Memorial University of Newfoundland, Canada (1992)
Memorial University of Newfoundland School of Medicine Graduate Fellowship, Canada (1991-1995)
Swedish Government Travel Fellowship for higher education

Specialty Area

  • Neuropharmacology; CNS Drug Targets and Discovery


Ph.D., Neuropharmacology, Memorial University of Newfoundland, Canada
Postdoctoral Fellowship in Neuropsychopharmacology, Indiana University School of Medicine, Indianapolis, USA