Saikat Basu

Bridging the ENG-MED disconnect through discoveries and extensions from classical fluid mechanics and biomathematical modeling, with core contributions in areas of airborne transmission of diseases through respiratory routes and cancer flow physics.

• 2024, ASME Rising Star of Mechanical Engineering
• 2024, NSF CAREER Award
• 2024, Outstanding Researcher Award, Jerome J. Lohr College of Engineering, South Dakota State University
• 2024, Faculty Award for International Research, Office of International Affairs, South Dakota State University
• 2023, Grantswinship Award, Jerome J. Lohr College of Engineering, South Dakota State University
• 2023, Early Career Investigator of the Year, Jerome J. Lohr College of Engineering, South Dakota State University
• 2018, Fluid Dynamics Research Prize, Japan Society of Fluid Mechanics
• 2015, Nomination for Outstanding Doctoral Dissertation, Virgina Tech
• 2013, Paul Torgersen Research Excellence Award
• 2010, Bechtel Travel Fellowship, Virginia Tech
• 2009, Pratt Presidential Graduate Fellowship, Virginia Tech
• 2008, Summer Fellowship, IASc India
• 2007, Summer Fellowship, JNCASR India
• 2004, National Merit Scholarship Certificate, India

• The Contagion Science: Integration of inhaled transport mechanics principles inside the human upper respiratory tract at multi scales. NSF CAREER Award, January 2024 - December 2028, $540,428.
• CAREER supplement : The Contagion Science: Integration of inhaled transport mechanics principles inside the human upper respiratory tract at multi scales. NSF Supplemental Award for Travel (an NSF - European Research Council Mechanism), January 2024 - December 2028, $17,058.
• Computational and theoretical fluid mechanics modeling for transport in dense tumors. NIH COBRE RPL Grant, March 2023, February 2026, $450,000.
• Sponsored collaboration with Aptar Pharma: Designing targeted carrier solutions for intranasal vaccines. Industry-Sponsored Project, August 2022 - May 2024, $66,066.
• Collaborative Research: New Generation of a Bio-inspired Protective Mask Based on Thermal and Vortex Traps. NSF CBET RAPID Grant, May 2020 - April 2022, $62,824.
• Computational tracking of perfusion in solid tumors. NIH COBRE Pilot Grant, April 2021 - July 2022, $49,999.
• Improving topical drug delivery for treatment of chronic rhinosinusitis using CFD, NIH R01 Subcontract from UNC Chapel Hill, April 2019 - May 2020, $20,021.
  Development of a digital platform to assess targeted regional drug delivery for airway sites. Haarberg Drug, Disease and Delivery (3D Center) Center Exploratory Grant, April 2023 - June 2024, $99,710.
• 'Peak band' vs. 'Monotonic decay': exploring particle deposition and penetration in anatomic cavities. Haarberg 3D Center Award for Undergraduate Research Support, February 2023 - June 2023, $3,000.
• Use of CFD to track respiratory transport in the throat. Scholarly Dissemination Award from SDSU Office of Academic Affairs, November 2019 - May 2020, $500.
• CFD-based identification of optimal particle sizes for targeted drug delivery at laryngeal granulomas. NIH NCATS Pilot Grant 2KR971701 awarded through UNC-CH, February 2018 - May 2019, $2,000.

1. S Basu, LP Chamorro, M Yeasin, MA Stremler. Modeling the effect of vorticity on inhaled transport in the upper airway. arXiv: 2406.09708, under review, submitted 7/2024.
2. S Basu. On the mechanics of inhaled bronchial transmission of pathogenic microdroplets generated from the upper respiratory tract, with implications for infection onset. arXiv: 2406.17895, under review, submitted 6/2024.
3. Z Wu, S Basu, S Kim, M Sorrells, FJ Beron-Vera, S Jung. Coherent spore dispersion via drop-leaf interactions. Science Advances, Volume 10(5), eadj8092, 2024.
4. MMH Akash, Y Lao, PA Balivada, P Ato, NK Ka, A Mituniewicz, Z Silfen, J Suman, A Chakravarty, D Joseph-McCarthy, S Basu. On a model-based approach to improve intranasal spray targeting for respiratory viral infections. Frontiers in Drug Delivery, Sec. Respiratory Drug Delivery, Volume 3, 1164671, 2023.
5. MMH Akash, N Chakraborty, J Mohmmad, K Reindl, S Basu. Computational multiphase characterization of perfusion trends inside biomimetic reduced-order dense tumors. Experimental and Computational Multiphase Flow, Volume 5(3), 319-329, 2023.
6. J Yuk, MMH Akash, A Chakraborty, S Basu, LP Chamorro, S Jung. Morphology of pig nasal structure and modulation of airflow, thermal conditioning, and olfactory functionality. Integrative and Comparative Biology, Volume 63(2), 304-314, 2023.
7. DV Egeren, M Stoddard, A Malakar, D Ghosh, A Acharya, S Mainuddin, B Majumdar, D Luo, R Nolan, D Joseph-McCarthy, LF White, NS Hochberg, S Basu, A Chakravarty. No magic bullet: limiting in-school transmission in the face of variable SARS-CoV-2 viral loads. Frontiers in Public Health, Sec. Infectious Diseases: Epidemiology and Prevention, Volume 10, 941773, 2022.
8. S Basu, UA Khwaja, SAA Rizvi, MA Sanchez-Gonzalez, G Ferrer. Evaluation of Patient Experience for a Computationally-Guided Intranasal Spray Protocol to Augment Therapeutic Penetration: Implications for Effective Treatments for COVID-19, Rhinitis, and Sinusitis. Medical Research Archives, Volume 10(4), 2022.
9. J Yuk, A Chakraborty, S Cheng, CI Chung, A Jorgensen, S Basu*, LP Chamorro*, S Jung*. On the design of particle filters inspired by animal noses. Journal of The Royal Society Interface, Volume 19(188), 20210849 | * all corresponding authors, 2022.
10. S Basu, MMH Akash, NS Hochberg, BA Senior, D Joseph-McCarthy, A Chakravarty. From SARS-CoV-2 infection to COVID-19 morbidity: an in silico projection of virion flow rates to the lower airway via nasopharyngeal fluid boluses. Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Volume 5(5), 10-18, 2022.
11. S Basu. Computational characterization of inhaled droplet transport to the nasopharynx. Scientific Reports (open-access, peer-reviewed journal from Nature), Volume 11(1), 6652, 2021.
12. MA Stremler, S Basu, E Masroor. Streamline patterns in 2P vortex street equilibria. Journal of Fluid Mechanics, Volume 901 E2, 1-4, 2020.
13. S Basu, LT Holbrook, K Kudlaty, O Fasanmade, J Wu, A Burke, BW Langworthy, M Mamdani, Z Farzal, WD Bennett, JP Fine, BA Senior, AM Zanation, CS Ebert Jr., A Kimple, B Thorp, DO Frank-Ito, GJM Garcia, JS Kimbell. Numerical evaluation of spray position for improved nasal drug delivery. Scientific Reports (open-access, peer-reviewed journal from Nature), Volume 10(1), 10568, 2020.
14. S Treat, CS Ebert Jr., Z Farzal, S Basu, AM Zanation, BD Thorp, JS Kimbell, BA Senior, AJ Kimple
    Intranasal corticosteroids: patient administration angles and impact of education. Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Volume 3, 160-166, 2020.
15. BM Brandon, WH Stepp, S Basu, JS Kimbell, BA Senior, WW Shockley, J Madison Clark. Nasal airflow changes with bioabsorbable implant, butterfly and spreader grafts. The Laryngoscope, Volume 130(12), E817-E823, 2020.
16. Z Farzal, S Basu, A Burke, O Fasanmade, E Mamuyac, W Bennett, CS Ebert Jr., A Zanation, BA Senior, JS Kimbell. Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients. International Forum of Allergy and Rhinology,  Volume 9(7), 746-758, 2019.
17. LF Tracy, S Basu, P Shah, DO Frank-Ito, S Das, A Zanation, JS Kimbell. Impact of endoscopic craniofacial resection on simulated nasal airflow and heat transport. International Forum of Allergy and Rhinology, Volume 9(8), 900-909, 2019

Working preprints

1. S Basu, A Malakar, MMH Akash. A mechanistic model for smallpox transmission via inhaled aerosols inside respiratory pathways. arXiv, DOI: 10.48550/arXiv.2403.04064, uploaded 2024 [pdf].
2. ML Tesch, A Malakar, SAA Rizvi, MMH Akash, G Ferrer, S Basu. Enhancing intranasal therapeutic penetration for treating respiratory illness: A clinical human factor feasibility study. Preprints.org, DOI: 10.20944/preprints202312.1002.v1, uploaded 2023 [pdf].
3. S Basu. Approaching Fermat's Conjecture from the Principle of Mathematical Induction
   Logic and Philosophy of Mathematics eJournal, SSRN 4023652, uploaded 2022 [pdf].
4. S Das and S Basu. On a model-based analysis of vortex formations and decay in flows through bio-inspired T-shaped cavities. arXiv, DOI: 10.48550/arXiv.2211.06964, uploaded 2022 [pdf].

Prior to SDSU

1. JS Kimbell, S Basu, GJM Garcia, DO Frank-Ito, FB Lazarow, E Su, DE Protsenko, Z Chen, J Rhee, BJ Wong. Upper airway reconstruction using anatomic optical coherence tomography: effects of airway bend on airflow resistance. Lasers in Surgery and Medicine, Volume 51(2), 150-160, 2019.
2. S Basu, DO Frank-Ito, JS Kimbell. On computational fluid dynamics models for sinonasal drug transport: relevance of nozzle subtraction and nasal vestibular dilation. International Journal for Numerical Methods in Biomedical Engineering, Volume 34(4), e2946, 2018.
3. E Perkins, S Basu, GJM Garcia, R Buckmire, R Shah, JS Kimbell. Ideal particle sizes for inhaled steroids targeting vocal granulomas: preliminary study using computational fluid dynamics. Otolaryngology – Head and Neck Surgery, Volume 158(3), 511-519, 2018.
4. BM Brandon, GK Austin, G Fleischman, S Basu, JS Kimbell, WD Shockley, J Madison Clark. Comparison of airflow between spreader and butterfly grafts using computational fluid dynamics in cadaveric models. JAMA Facial Plastic Surgery, Volume 20(3), 215-221, 2018.
5. JS Kimbell, S Basu, Z Farzal, BA Senior. Characterizing nasal delivery in 3D models before and after sinus surgery. Respiratory Drug Delivery, Volume 1, 181-188, 2018.
6. S Basu, A Yawar, A Concha, MM Bandi. On angled bounce-off impact of a drop impinging on a flowing soap film. Fluid Dynamics Research, Volume 49(6), 065509, 2017 | Awarded Fluid Dynamics Research Prize 2018.
7. S Basu and MA Stremler. Exploring the dynamics of 2P wakes with reflective symmetry using point vortices. Journal of Fluid Mechanics, Volume 831, 72-100, 2017.
8. S Basu and MA Stremler. On the motion of two point vortex pairs with wake-inspired glide-reflective symmetry in a periodic strip. Physics of Fluids, Volume 27(10), 103603, 2015.
9. MA Stremler and S Basu. On point vortex models of exotic bluff body wakes. Fluid Dynamics Research, Volume 46(6), 061410, 2014.
10. MA Stremler, A Salmanzadeh, S Basu, CHK Williamson. A mathematical model of 2P and 2C vortex wakes. Journal of Fluids and Structures, Volume 27(5-6),  774-783, 2011.

Working preprint

1. SB Sreenath, JS Kimbell, S Basu, AJ Coniglio, TE Fontenot, BD Thorp, CS Ebert, BA Senior, AM Zanation. Comparative Analysis of the Main Nasal Cavity and the Paranasal Sinuses in Chronic Rhinosinusitis: An Anatomic Study of Maximal Medical Therapy. arXiv, DOI: 10.48550/arXiv.1811.00649, uploaded 2018