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Saikat Basu

Basu_June2020

Title

Assistant Professor

Office Building

Crothers Engineering Hall

Office

216

Mailing Address

Crothers Engineering Hall 216
Mechanical Engineering-Box 2219
University Station
Brookings, SD 57007

Biography

The Basu Lab is currently housed at the Department of Mechanical Engineering at South Dakota State University. We leverage tools from theoretical and computational fluid mechanics, and in collaboration with several experimental groups, our focus is on addressing interdisciplinary questions within the biomedical context.

Long-term goals of our research program include:
(a) rendering computational modeling available as a planning tool for surgeons and clinicians while treating flow-based pathologies;
(b) connecting flow physics of respiratory transport with state-of-the-art virologic and pharmaceutic data to enhance our preparedness for airborne pathogenic transmissions.

Ongoing projects are in the areas of drug delivery and transport physics in the upper airway, respiratory transmissions inside anatomic cavities and through the outside-environment, design of bio-inspired new-generation filtration technologies, and perfusion mechanics in dense cancerous tumors. Amongst other topics, we have tertiary projects in the area of vortex wake dynamics, with applications such as flow-induced clean energy innovations and vortex-entrapment of therapeutic particles in clinical flows. For analysis and scientific computations, apart from fluid mechanics based approaches, we also use tools from dynamical systems theory. To validate the reliability of our computational and theoretical findings, we frequently collaborate with other groups, from both clinical and experimental backgrounds.

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Dr. Basu's recent collaborative work on interfacial mechanics has been recognized with the Fluid Dynamics Research Prize (2018) of the Japan Society of Fluid Mechanics. His doctoral dissertation on vortex wake dynamics was nominated for the outstanding dissertation award and was also awarded the Paul Torgersen Research Award, both at Virginia Tech. Basu's research on respiratory flow physics has been covered on popular press by ScienceDaily, NewsWise, and by other international media outlets in Europe.

Education

Virginia Tech, Department of Biomedical Engineering and Mechanics: PhD, Engineering Mechanics (2014)
Jadavpur University, India: BE, Civil Engineering (2009)

Academic Interests/Expertise

Theoretical and Computational Fluid Dynamics

Academic Responsibilities

Taught courses
- Engineering Mechanics in Biomedical Applications (ME 446/546 at SDSU)
- Mechanical Design Technologies (ME 212 at SDSU)
- Skeletal Biomechanics (Fall 2018, UNC Chapel Hill)
- Statics (Fall 2017, UNC Chapel Hill)
- Nonlinear Dynamics (Spring 2016, OIST - Japan)
- Statics (Spring 2014, Virginia Tech)
- Fluid Mechanics I, II (Summer 2012, Virginia Tech)

Committee Activities

Member, NSF Grant Review Panels (2020)
Member, SDSU Faculty Senate (2019 - 2020)
Chair, Smithies Nobel Symposium Planning Sub-Committee, UNC Chapel Hill (2017)

Awards and Honors

- Fluid Dynamics Research Prize (Japan Society of Fluid Mechanics, 2018)
- Nomination for Outstanding Doctoral Dissertation (Virginia Tech, 2015)
- Paul E. Torgersen Research Excellence Award (Virginia Tech, 2013)
- Bechtel Travel Fellowship (Virginia Tech, 2010)
- Pratt Presidential Graduate Fellowship (Virginia Tech, 2009)
- Summer Fellowship (IASc India, 2008)
- Summer Fellowship (JNCASR India, 2007)
- National Merit Scholarship Certificate (India, 2004)

Grants

1. NSF RAPID Grant 2028069 for COVID-19
"Collaborative Research: New Generation of a Bio-inspired Protective Mask Based on Thermal & Vortex Traps"
Period: 05/2020 – 04/2021 | Amount: $199,712
Grant Role: Co-Principal Investigator (with S Jung at Cornell University and L Chamorro at UIUC)

2. NIH COBRE Pilot Grant - Project Number 5P20GM109024-04
Computational tracking of drug uptake in solid tumors
Period: 01/2021 - 12/2021 | Amount: $49,999
Grant Role: Principal Investigator

3. Scholarly Dissemination Award from SDSU Office of Academic Affairs
"Use of CFD to track respiratory transport in the throat"
Period: 11/2019 – 05/2020 | Amount: $500
Grant Role: Principal Investigator

4. NIH R01 Subcontract (PI: JS Kimbell, UNC-CH)
"Improving topical drug delivery for treatment of chronic rhinosinusitis using CFD"
Period: 04/2019 - 03/2020 | Amount: $20,021
Grant Role: Subcontract Principal Investigator

5. NIH NCATS Pilot Grant 2KR971701 awarded through UNC-CH
"CFD-based identification of optimal particle sizes for targeted drug delivery at vocal folds"
Period: 02/2018 – 05/2019 | Amount: $2000
Grant Role: Principal Investigator

Professional Memberships

American Physical Society
International Society for Aerosols in Medicine

Work Experience

Assistant Professor, tenure-track: South Dakota State University, USA (01/2019 - Present)
Postdoctoral Fellow: UNC Chapel Hill, USA (2016 - 2018)
Adjunct Faculty: UNC/NC State University, USA (2017 - 2018)
Postdoctoral Scholar: OIST, Japan (2014 - 2016)
Graduate Assistant: Virginia Tech, USA (2009 - 2014)
Summer Intern: DLR - Braunschweig, Germany (2008)

Area(s) of Research

JOURNAL PUBLICATIONS

21. S Basu, UA Khwaja, SAA Rizvi, MA Sanchez-Gonzalez, G Ferrer
Evaluation of Patient Experience for a Computationally-Guided Intranasal Spray Protocol to Augment Therapeutic Penetration: Implications for Effective Treatments for COVID-19, Rhinitis, and Sinusitis
Medical Research Archives, Volume 10(4), 2022

20. S Basu
Approaching Fermat's Conjecture from the Principle of Mathematical Induction
Logic & Philosophy of Mathematics eJournal, available at SSRN 4023652, 2022

19. J Yuk, A Chakraborty, S Cheng, CI Chung, A Jorgensen, S Basu*, LP Chamorro*, S Jung*
On the design of particle filters inspired by animal noses
Journal of The Royal Society Interface, Volume 19, Article number 20210849 | * all corresponding authors, 2022

18. S Basu, MMH Akash, NS Hochberg, BA Senior, D Joseph-McCarthy, A Chakravarty
From SARS-CoV-2 infection to COVID-19 morbidity: an in silico projection of virion flow rates to the lower airway via nasopharyngeal fluid boluses
Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Volume 5, 2022

17. S Basu
Computational characterization of inhaled droplet transport to the nasopharynx
Scientific Reports (open-access, peer-reviewed journal from Nature), Volume 11, Article number 6652, 2021

16. MA Stremler, S Basu, E Masroor
Streamline patterns in 2P vortex street equilibria - Corrigendum
Journal of Fluid Mechanics, Volume 901, 2020

15. S Treat, CS Ebert Jr., Z Farzal, S Basu, AM Zanation, BD Thorp, JS Kimbell, BA Senior, AJ Kimple
Intranasal corticosteroids: patient administration angles and impact of education
Rhinology Online (open-access, peer-reviewed journal from European Rhinologic Society), Volume 3, 2020

14. S Basu, LT Holbrook, K Kudlaty, O Fasanmade, J Wu, A Burke, BW Langworthy, M Mamdani, Z Farzal, WD Bennett, JP Fine, BA Senior, AM Zanation, CS Ebert Jr., A Kimple, B Thorp, DO Frank-Ito, GJM Garcia, JS Kimbell
Numerical evaluation of spray position for improved nasal drug delivery
Scientific Reports (open-access, peer-reviewed journal from Nature), Volume 10, Article number 10568, 2020

13. BM Brandon, WH Stepp, S Basu, JS Kimbell, BA Senior, WW Shockley, J Madison Clark
Nasal airflow changes with bioabsorbable implant, butterfly and spreader grafts
The Laryngoscope, Published online, DOI: 10.1002/lary.28691, 2020

12. Z Farzal, S Basu, A Burke, O Fasanmade, E Mamuyac, W Bennett, CS Ebert Jr., A Zanation, BA Senior, JS Kimbell
Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients
International Forum of Allergy & Rhinology, Published online, DOI: 10.1002/alr.22324, 2019

11. LF Tracy, S Basu, P Shah, DO Frank-Ito, S Das, A Zanation, JS Kimbell
Impact of endoscopic craniofacial resection on simulated nasal airflow and heat transport
International Forum of Allergy & Rhinology, Published online, DOI: 10.1002/alr.22328, 2019

Journal publications before SDSU:

10. JS Kimbell, S Basu, GJM Garcia, DO Frank-Ito, FB Lazarow, E Su, DE Protsenko, Z Chen, J Rhee, BJ Wong
Upper airway reconstruction using anatomic optical coherence tomography: effects of airway bend on airflow resistance
Lasers in Surgery and Medicine, Volume 51(2), 2019

9. S Basu, DO Frank-Ito, JS Kimbell
On computational fluid dynamics models for sinonasal drug transport: relevance of nozzle subtraction and nasal vestibular dilation
International Journal for Numerical Methods in Biomedical Engineering, Volume 34 (4), 2018

8. E Perkins, S Basu, GJM Garcia, R Buckmire, R Shah, JS Kimbell
Ideal particle sizes for inhaled steroids targeting vocal granulomas: preliminary study using computational fluid dynamics
Otolaryngology – Head and Neck Surgery, Volume 158(3), 2018

7. BM Brandon, GK Austin, G Fleischman, S Basu, JS Kimbell, WD Shockley, J Madison Clark
Comparison of airflow between spreader and butterfly grafts using computational fluid dynamics in cadaveric models
JAMA Facial Plastic Surgery, Volume 20(3), 2018

6. JS Kimbell, S Basu, Z Farzal, BA Senior
Characterizing nasal delivery in 3D models before and after sinus surgery
Respiratory Drug Delivery, Volume 1, 181–188, 2018

5. S Basu, A Yawar, A Concha, MM Bandi
On angled bounce-off impact of a drop impinging on a flowing soap film
Fluid Dynamics Research, Volume 49, 2017

4. S Basu and MA Stremler
Exploring the dynamics of 2P wakes with reflective symmetry using point vortices
Journal of Fluid Mechanics, Volume 831, 2017

3. S Basu and MA Stremler
On the motion of two point vortex pairs with wake-inspired glide-reflective symmetry in a periodic strip
Physics of Fluids, Volume 27(10), 2015

2. MA Stremler and S Basu
On point vortex models of exotic bluff body wakes
Fluid Dynamics Research, Volume 46, 2014

1. MA Stremler, A Salmanzadeh, S Basu, CHK Williamson
A mathematical model of 2P and 2C vortex wakes
Journal of Fluids and Structures, Volume 27(5), 2011

PREPRINTS

4. DV Egeren, M Stoddard, A Malakar, D Ghosh, A Acharya, S Mainuddin, B Majumdar, D Luo, R Nolan, D Joseph-McCarthy, LF White, NS Hochberg, S Basu, A Chakravarty
No magic bullet: limiting in-school transmission in the face of variable SARS-CoV-2 viral loads
medRxiv, doi: https://doi.org/10.1101/2022.03.25.22272956, 2022

3. S Basu, MMH Akash, Y Lao, PA Balivada, P Ato, NK Ka, A Mituniewicz, Z Silfen, J Suman, A Chakravarty, D Joseph-McCarthy
A model-based approach to improve intranasal sprays for respiratory viral infections
medRxiv, doi: https://doi.org/10.1101/2022.01.26.22269854, 2022

2. MMH Akash, N Chakraborty, S Basu
Computational modeling of perfusion in dense solid tumors
arXiv: 2012.04095, 2021

1. SB Sreenath, JS Kimbell, S Basu, AJ Coniglio, TE Fontenot, BD Thorp, CS Ebert, BA Senior, AM Zanation
Comparative Analysis of the Main Nasal Cavity and the Paranasal Sinuses in Chronic Rhinosinusitis: An Anatomic Study of Maximal Medical Therapy
arXiv: 1811.00649, 2018

Applications of Research

Healthcare Innovations

OPEN POSITIONS
We are looking for motivated undergraduate and graduate students. If the group's research areas align with your general interests, email Prof. Basu (at Saikat.Basu@sdstate.edu) with your CV and a brief outline of your prior research experience, if any.