Omathanu Perumal

Omathanu Perumal

Title

Pharmaceutical Sciences Department Head/Professor

Office Building

Avera Health & Science Center

Office

275

Mailing Address

Avera Health & Science 275
College of Pharmacy-Box 2202C
University Station
Brookings, SD 57007

Education

Ph.D. (Pharmaceutics), National Institute of Pharmaceutical Education & Research (NIPER), India
M.Pharm (Pharmaceutics), Birla Institute of Technology, India
B.Pharm, Dr. M.G.R. Medical University, India

Academic Interests/Expertise

Pharmaceutics, Drug Delivery, Drug Formulation, Biopharmaceutics and Pharmacokinetics

Academic Responsibilities

Introduction to Advanced Concepts in Pharmaceutical Sciences
(PHA 720)
Advanced concepts in Pharmaceutics (PHA859)
Topics in Advanced Pharmaceutical Sciences (PHA 825)
Techniques in Pharmaceutical Sciences (PHA 846)
Pharmaceutics I (PHA 331)
Pharmaceutics II (PHA 332)

Specialty Area

  • Drug Delivery
  • Pharmaceutics
  • Topical and transdermal drug delivery
  • Oral drug delivery
  • Formulation

Awards and Honors

-Pat & Jo Canon Intellectual Property and Commercialization Award, South Dakota State University, Feb 2016.
-Interview appeared in the Dermatopharmaceutics Focus Group Newsletter of American Association of Pharmaceutical Scientists, Jun 2016.
-Drug delivery technology developed in our laboratory received the TechConnect National Innovation Award, 2014.
-South Dakota State University Leadership Academy, 2013-14
-Drug delivery technology developed in our laboratory received the 3rd prize in South Dakota Governor’s Giant Vision Competition, 2013.
-Academic Leadership Fellow, American Association of Colleges of Pharmacy, 2012-13
-Faculty Scholar, College of Pharmacy, South Dakota State University, 2012
-F.O. Butler Excellence Award for Research, South Dakota State University, 2012
-Intellectual Property and Commercialization Award, South Dakota State University, 2010
-Idea Prize, Brookings Economic Development Corporation, 2009, 2012
-Distinguished Researcher Award, South Dakota State University, 2009
-Dr. Patricia Wexler Research Grant Award from Skin Cancer Foundation, 2008


INVITED PRESENTATIONS
1. Invited Plenary Lecture titled “Food-grade biopolymer based nanocarriers for oral drug delivery applications” at the Biomaterials International Conference in Fukuoka, Japan, Aug 2017.
2. Invited Lecture titled “Food-grade biopolymer based nanocarriers for oral drug delivery applications” at the 7th China Nano Conference in Beijing, China, Aug 2017.
3. “Food-grade biopolymer based nanocarriers for oral drug delivery applications” Sichuan University, Chengdu, China, Aug 2017.
4. Panel Presentation: Innovation and Management of Intellectual Property, South Dakota State Univesity-Avera Research Symposium, Oct 27, 2016.
5. Virtual Panel on University IP and commercialization, organized by Michigan State University, Oct 2016.
6. Invited talk titled “Protein nanocarriers for drug delivery applications” 9th World Drug Delivery Summit, New Orleans, Jun 30-July 2, 2016.
7. Invited Plenary lecture titled “Novel Topical Drug Delivery Approaches” at the Annual Pharmaceutics Meeting of Chinese Pharmaceutical Association & Annual meeting of China Chapter of Controlled Release Society, Hangzhou, China, Oct 2015.
8. Invited Plenary Lecture titled “Protein Nanocarriers for drug delivery applications” at the Biomaterials International Conference, Kenting, Taiwan, June 2015.
9. Participated as a Panelist in the ‘Entrepreneurship: Inspiration and information’ organized by the South Dakota State University Graduate School, Brookings, SD, April 2015.
10. “Lessons Learned from University-based Entrepreneurs” Commercialization Conference, South Dakota Board of Regents, Apr 15, 2014 (Panel Discussion)
11. “It can happen here” SDU-Avera Research Symposium on Protecting and Commercializing University and Health Care Collaborative innovations Sept 11, 2013 (Panel Discussion)
12. “Dendrimers as skin drug delivery vehicles” Department of Chemistry, Western Kentucky University, Bowling Green, KY, Sept 2013.
13. “Corn based biomaterial for drug delivery applications” Plenary Lecture at the Biomaterials Day organized by the Biomaterials Chapter of University of South Dakota, Sioux Falls, SD, May 2013.
14. “Beginning from the end and end with the beginning”. Pharmacy Department, Birla Institute of Technology and Science, Hyderabad, India, Dec 11, 2012.
15. “Corn-based Protein Nanocarriers”. Department of Biomedical Engineering, University of South Dakota, Sioux Falls, SD, Oct 2012.
16. “Corn-based Protein Nanocarriers”. Arvind Eye Research Foundation, Madurai, India, Jan 6, 2012.
17. “From Corn to Cosmetics”. 2nd Skin Trailblazer Pre-Gordon Conference workshop held at Embassy Suites, Boston, MA, Aug 5-7, 2011. I was one of the co-organizers of this workshop
18. “Skin Drug Delivery’ 4th Annual South Dakota Biotechnology Summit and Annual meeting held at Sioux Falls, SD Sept 2009.
19. “Transcutaneous iontophoretic delivery of antisense oligonucleotide using nanocarriers”. Gordon Research Conference on Barrier Properties of Skin, Waterville Valley, NH, Aug 2009.
20. “Skin Penetration of Polymers”, Pre-Gordon Conference of International Society of Skin Physiology and Pharmacology, Boston, MA, Aug 2009.
21. “Breaching the Skin Barrier”, Department of Biomedical Engineering, University of South Dakota, Sioux Falls, SD, Oct 2008.
22. “Role of Biopharmaceutics and Pharmacokinetics in Drug Discovery & Development”, K.M. College of Pharmacy, Madurai, India, Aug 2008.
23. “Role of Biopharmaceutics and Pharmacokinetics in Drug Discovery & Development”, Department of Pharmaceutical Chemistry, Vellore Institute of Technology, Vellore, India, Jul 2008.
24. “Intracellular Drug Delivery”, College of Pharmacy, Midwestern University, Chicago, IL, Feb 2005.
25. “Breaching the Skin Barrier”, College of Pharmacy, Temple University, Philadelphia, PA, Sept 2004.
“Transdermal Iontophoresis of Insulin”, Department of Chemical Engineering, Wayne State University, Detroit, MI, Nov 2003.

Grants

1. Novel Polyphenol Fortified Profile Diet Formulation Role: Principal Investigator
Agency: SDSU-Sanford Research Initiative Total award: $96,663 (Sept 2015- Aug 2017)
The goal was to develop food-grade protein biopolymer based nanocarriers for enhancing the oral bioavailability of epigallocatechin and investigating the feasibility of incorporating into Sanford Profile diet formulations.

2. Topical Delivery of 4-hydroxy tamoxifen to the breast Role: Research Advisor
Agency: Women in Giving, SDSU Foundation Total award: $1,500 (Jan-Dec 2016)
This research grant is for supporting the graduate student’s research project. The goal of this study was to develop topical formulations of 4-hydroxy tamoxifen and test the delivery and chemopreventive efficacy in a rat breast tumor model.

3. Bioengineering of milk proteins to design novel nanocarriers for drug delivery Role: Co-Principal Investigator
Agency: Mid-west Dairy Association Total award: $13,171 (Jan-Dec 2015)
The goal was to explore the feasibility of developing nanoparticles using milk proteins using curcumin as a model compound.
4. Novel intraductal delivery system for breast cancer Role: Research Advisor
Agency: Women in Giving, SDSU Foundation Total award: $500 (Jan-Dec 2015)
This research grant is for supporting the graduate student’s research project. The goal of this study was to explore the feasibility of intra-ductal delivery of chemotherapeutic agents to the breast.

5. Therapy for Secondary Lymphedema in Breast Cancer Role: Consultant
Agency: SBIR, Phase-I, National Institutes of Health Total award: $155,000 (Jan-Dec 2014)
The goal was to develop a sustained release delivery system for growth factors using natural biodegradable protein biopolymer for regeneration of lymphatic vessels. The delivery system used in this project by the start-up company (Medgene Laboratories) was a delivery platform developed in my laboratory.

6. Novel topical therapeutic strategy for breast cancer Role: Research Advisor
Agency: Women in Giving, SDSU Foundation Total award: $2,000 (Jan-Dec 2014)
This research grant is for supporting the graduate student’s research project. The goal of this study was to explore the feasibility of delivering compounds to the breast through topical application.

7. Developing an in-vivo imaging facility at South Dakota State University Role: Co-investigator
Agency: South Dakota Board of Regents Total award: $100,000 (Nov 2014-May 2016)
The goal of this collaborative grant with investigators from multiple departments was to purchase an in-vivo imaging equipment for biomedical, pharmaceutical and biological research. As the Department head, I worked with other departments to get matching funds ($75,000) to purchase this equipment.

8. Topical Delivery of anti-cancer agents Role: Research Advisor
Agency: Egyptian Cultural Mission Bureau, Washington D.C. Total award: $20,000 (Nov 2013- Nov 2015)
This fund is for supporting the graduate student’s research project. The goal of this study was to develop topical formulations for the delivery of anti-cancer agents to the breast.

9. Zein nanoparticles for topical drug delivery Role: Principal Investigator
Agency: South Dakota Innovation Partners Total award: $260,000 (Mar 2010-Mar 2013)
The goal of this industry-funded project was to develop skin delivery systems for retinoids using zein nanoparticles developed in my laboratory.

10. Topical Delivery of chemopreventive agents to the breast Role: Research Advisor
Agency: Saudi Arabian Cultural Mission, Washington, DC
Total award: $5,000 (Aug 2014-Aug 2015)
This fund is for supporting the graduate student’s research project. The goal of this study was to develop topical formulations for the delivery of chemopreventive agents to the breast.

11. Multifunctional nanotherapeutic system for advanced prostate cancer Role: Principal Investigator
Agency: Prostate Cancer Research Program, Department of Defense Total award: $105,153 (Sept 2011- Sept 2013)
The goal was to explore the feasibility of developing a dendrimer-based multifunctional delivery system consisting of docetaxel and siRNA for eIF4E.

12. Pre-clinical studies of topical tetracycline formulation Role: Co-Principal Investigator
Agency: pharmaCline LLC., Sioux Falls Total award: $99,684 (Jun-Dec 2011)
The goal of this industry-funded project was to study the in-vitro and in-vivo performance of topical tetracycline formulations.

13. Zein-based nanoparticles for oral drug delivery applications Role: Research Advisor
Agency: Saudi Arabian Cultural Mission, Washington, DC Total award: $100,000 (Mar 2010- Mar 2014)
This fund is for supporting the graduate student’s research project. The goal of this study was to develop core-shell zein nanoparticles for oral drug delivery applications.

14. Novel nanomicellar skin delivery system for curcumin Role: Principal Investigator
Agency: US Small Business Administration Total award: $44,500 (Oct 2010-Jun 2011)
The goal was to develop and test curcumin encapsulated PEG-zein micelle delivery system for topical delivery through skin.

15. Translational Cancer Research Center
Role: Director (2013-15), Associate Director (2011-12), Principal Investigator (2009-15),
Agency: Research Commercialization Council, South Dakota Board of Regents Total award: $2.39 million (Mar 2009-Jun 2015)
The goal of this multidisciplinary research center is to develop new chemopreventive and chemotherapeutic strategies for skin, breast, prostate and head/neck cancers. As one of the PI’s in the center, I received $300,000 to develop zein nanoparticle-based delivery systems for anticancer agents.

16. Transcutaneous delivery of DNA-dendrimer complex using iontophoresis Role: Principal Investigator
Agency: Research Support Fund, South Dakota State University Total award: $7,500 (Mar 2009-Mar 2010)
The goal of this study was to test the feasibility of developing a topical gene therapy using dendrimer and iontophoresis.

17. Acquisition of Differential Scanning Calorimeter Role: Co-Principal Investigator
Agency: United States Department of Agriculture
Total award: $50,530 (Jan-Dec 2009)
The goal of this collaborative grant with Department of Agriculture Engineering was to purchase Differential Scanning Calorimeter for pharmaceutical and food analysis. The total amount includes 50% institutional match.

18. Zein Nanoparticles for Drug Delivery Applications Role: Principal Investigator
Agency: Competitive research seed grant, South Dakota Board of Regents Total award: $193,000 (Aug 2008-Dec 2010)
The goal of this study was to develop and test zein nanoparticles for systemic drug delivery applications.

19. Feasibility study for topical delivery of azithromycin Role: Principal Investigator
Agency: Minotech Engineering, Boston, MA Total award: $3,500 (Apr-Jun 2008)
The goal of this study was to test the feasibility of developing a topical delivery system for azithromycin for tick-borne diseases.

20. Transcutaneous Delivery of Bcl-2 anti-sense oligonucleotide for skin cancer treatment Role: Principal Investigator
Agency: Skin Cancer Foundation, New York, NY. Total award: $10,000 (Apr 2008-Mar 2009)
The goal of this study was to develop Bcl-2 anti-sense oligonucleotide dendrimer complex and test its delivery, and efficacy in a skin cancer mouse model.

21. Dendritic Nanopolymers as Potential Drug Delivery Vehicles for Vascular Endothelial Cells Role: Principal Investigator
Agency: Research Support Fund, South Dakota State University Total award: $7,500 (Apr 2007-Mar 2008)
The goal of this study was to test the feasibility of using dendrimers for intracellular delivery to vascular endothelial cells.

22. Novel nanoparticles of corn protein, zein for intracellular delivery Role: Principal Investigator
Agency: South Dakota Corn Utilization Council; Total award: $74,000 (July 2006-Jun 2008)
The goal of this study was to explore the feasibility of developing zein nanoparticles and test the potential for intracellular drug delivery.

23. Dendritic nanopolymers as novel vehicles for Transdermal Drug Delivery Role: Principal Investigator
Agency: Individual Research Seed Grant, South Dakota Board of Regents Total award: $42,948 (Aug 2006-Aug 2007)
The goal of this study was to study the structure-permeability relationship of dendrimers for transdermal drug delivery applications.

24. Dendritic nanopolymers as transdermal permeation enhancers Role: Principal Investigator
Agency: Seed Grant, Research Office, South Dakota State University
Total award: $9,500 (Sept 2005-Aug 2006)
The goal of this study was to study the skin permeation enhancing properties of dendrimers.

Patents

1. Perumal, O., Muthunayagam, V., Alsharif, F.M., Islam, S. Method of forming zein nanoparticles for effective oral delivery of plant polyphenols. US provisional patent application filed in Apr 2017.
2. Perumal, O., Alqahtani, M. Novel core-shell nanoparticles for oral drug delivery systems. US/PCT Patent Application Filed in Jun 2014.
3. Perumal, O., Podaralla, S., Kaushik, R. Method of forming non-immunogenic hydrophobic protein nanoparticles and uses thereof. International Patent, US/PCT (WO 2009/137112A1). http://www.wipo.int/pctdb/en/wo.jsp?WO=2009137112. US Patent issued in Jan 2014, issued in Japan in Dec 2015 and in Canada in July 2017. This technology Licensed to a Brookings based Start-up company, Tranzderm Solutions (www.tranzdermsolutions.com). This is the first technology licensed from SDSU.
4. Perumal, O., Podaralla, S. Polymer conjugated protein micelles, US/PCT Patent application (WO 2012/116272A2). US Patent issued in Jan 2014 (Licensed to Tranzderm Solutions, Brookings, SD)
5. Perumal, O., Averineni, RK., Podaralla, S., Alqahatani, M. Protein Nanocarriers for topical delivery, US/PCT application (US2012/0195947A1). US Patent issued in Jan 2016 (Licensed to Tranzderm Solutions, Brookings, SD)
6. Perumal, O., Dave, K., Dwivedi, C. and Santha, S. Composition and methods for localized drug delivery through mammay papillae, US patent application issued in Dec 2015. (Licensed to Tranzderm Solutions, Brookings, SD)
7. Perumal, O., and Averineni RK. Methods of treating skin disorders using nanoscale delivery devices and transdermal enhancing compositions. Patent Filed in Aug 2013 (Licensed to Tranzderm Solutions, Brookings, SD).

Professional Memberships

Editor-In-Chief Journal of Biomedical Nanotechnology (2011-2017, IF-4.532);

American Editor Journal of Biomedical Nanotechnology (2010)

Associate Editor Journal of Biomedical Nanotechnology (2007-2008)
Member Consumer and Diversified Programming Committee, Controlled Release Society (2011-14);
Mamber, Graduate studies and research special interest group, American Association of Colleges of Pharmacy (2014-);
Member, Pharmaceutics section, American Association of Colleges of Pharmacy (2014-)
Member, Dermatopharmaceutics section, American Association of Pharmaceutical Scientists.
Workshop/Conference Co-organized Pre-Gordon Skin Trailblazer workshop in Boston, 2011
Chaired a mini-session at the Annual meeting of American Association of Colleges of Pharmacy, 2017
Chaired a session on Nanomedicine and Bionanotechnology in China Nano Conference, 2017.
Ph.D. Thesis Examiner All India Institute of Medical Sciences; Dr. M.G.R. Medical
University; Manipal University; Anna University, Bharathidasan University, SASTRA University, India; National Institute of Pharmaceutical Education and Research, India; University of Queensland, Australia.

PROFESSIONAL AFFILIATIONS
American Association of Colleges of Pharmacy
American Association of Pharmaceutical Scientists

Work Experience

Graduate Program
Coordinator 2017-present; Ph.D. Program in Pharmaceutical Sciences,
South Dakota State University, Brookings, SD

Head: 2013- present; Department of Pharmaceutical Sciences, South Dakota
State University, Brookings, SD

Director: 2013-15; Translational Cancer Research Center, Brookings, SD
Associate Director: 2012-13, Translational Cancer Research Center, Brookings, SD
Professor 2014-Present, South Dakota State University, Brookings, SD
Associate Professor: 2009-2012 (Tenured); South Dakota State University, Brookings, SD
Assistant Professor: 2005-2008; South Dakota State University, Brookings, SD
Postdoctoral Fellow: 2004-2005; Wayne State University, Detroit, MI
Postdoctoral Scholar: 2003; University of Kentucky, Lexington, KY
Research Scientist: 2002; Ranbaxy Research Laboratories, Gurgaon, India
Senior Research Fellow: 1998-2002; National Institute of Pharmaceutical Education &
Research, India
Lecturer: 1997; Ultra College of Pharmacy, Madurai, India
Junior Research Fellow: 1995-1997; Birla Institute of Technology, Ranchi, India

Area(s) of Research

The central tenet of our research is to develop new drug delivery systems at the interface of material and biological sciences based on a 3D approach (Disease, Drug & Destination. Current Research in our group is focused on the following research areas:

1.Transdermal drug delivery systems for breast cancer and skin diseases
2. Pediatric oral drug delivery systems
3. Food-grade biopolymer based nanocarriers for various drug delivery applications.

The research outcomes from our research have significant practical applications in the following areas
1. Localized therapeutic approaches for breast cancer that maximizes the drug concentration at the target site in the breast and minimizes systemic side effects of chemotherapeutic agents.
2. Effective and safe oral pediatric formulations using food-grade biopolymers.

Applications of Research

PUBLICATIONS
In some of the papers middle name ‘Pillai’ is used.
1. Dave, K., Alsharif, F., Islam, S., Dwivedi, C., Perumal, O. Chemoprevention of breast cancer by transdermal delivery of santalol through breast skin and mammary papilla (nipple). Pharm. Res. 34: 1897-1907, 2017
2. Alqahtani, M., Islam, M.S., Podaralla, S., Kaushik, R.S., Reineke, J., Woyengo, T., Perumal, O.: Food protein based core-shell nanocarriers for oral drug delivery: Effect of shell composition on in vitro and in vivo functional performance of zein nanocarriers. Mol. Pharm. 14: 757-769, 2017.
3. Alsharif, F.M., Dave, K., Samy, A.M., Saleh, K.I., Amin, M.A., Perumal,O. Influence of hydroalcoholic vehicle on in-vitro transport of 4-hydroxy tamoxifen through the mammary papilla (Nipple). AAPS PharmSciTech 18: 1366-1373, 2017.
4. Dave, K., Perumal, O. Transpapillary (Nipple) delivery of macromolecules to the breast: Proof of concept study. Mol. Pharm. 13: 3842–3851, 2016.
5. Dave, K., Averineni, R., Sahdev, P., Perumal, O. Transpapillary drug delivery to the breast;
PLOS ONE 9(12): e115712. doi:10.1371/journal.pone.0115712, 2015.
6. Venuganti, V., Saraswathy, M., Dwivedi, C., Kaushik, R., Perumal, O. Topical Gene Silencing by iontophoretic delivery of antisense oligonucleotide-dendrimer nanocomplex: Proof of concept in a skin cancer mouse model. Nanoscale. 7, 3903-3914, 2015,
7. Vyas, A., Chaturvedi LS., Perumal, O., Vyas, D. Applications of nanomedicine in breast cancer, detection, imaging and therapy. J. Nanosci. Nanotechnol. 14, 1–11, 2014
8. Perumal, O., Murthy, N., Kalia, Y. Transdermal drug delivery-past, present and future. Skin Pharmacol. Physiol. 26: 331-342, 2013.
9. Sahdev P., Podaralla., S., Kaushik, R., Perumal, O.: Calcium Phosphate nanoparticles for transcutaneous vaccine delivery. J. Biomed. Nanotechnol. 9, 1-10, 2012.
10. Podaralla., S., Averineni, R., Perumal, O.: Synthesis of novel biodegradable methoxy poly(ethylene glycol)-zein micelles for effective delivery of curcumin. Mol. Pharm. 9: 2778- 2786, 2012.
11. Podaralla., S., Perumal, O.: Factors influencing the preparation of zein nanoparticles. AAPS Pharm. Sci. Tech. 3: 919-927, 2012.
12. Kumar, S., Sahdev, P., Perumal, O., Tummala, H.: Identification of novel skin penetration enhancement peptide by phage display peptide library screening. Mol. Pharm. 9, 1320-1330, 2012.
13. Venuganti.,V., Hildreth, M., Guan, X., Perumal, O.: Structure skin permeability relationship of dendrimers. Pharm. Res. 28: 2246-2260, 2011.
14. Perumal, O., Michniak, B., Touitou, E., Roberts, M.: Skin Nanotechnology. J. Biomed. Nanotechnol. 6, 405-407, 2010.
15. Podaralla, S., Perumal, O.: Preparation of Zein Nanoparticles by pH controlled Nanoprecipitation. J. Biomed Nanotechnol 6: 312-317, 2010.
16. Perumal, O., Khandare, J., Kolhe, P., Kannan, RM., Kannan, S., Lieh-Lai, M.: Influence of spacer and branching architecture on cell entry and activity of drug-polymer conjugates.
Bioconjugate Chem. 20: 842-846 2009. (Paper cited as ‘Must Read’ in Faculty Biology 1000).
17. Venuganti, V., Perumal, O: Effect of Dendrimer charge, generation and concentration on Skin Permeation of 5-Fluorouracil. J. Pharm. Sci. 98: 2345-2356, 2009.
18. Sarkar, M., Perumal, O., Panchagnula, R.: Solid state characterization of Nevirapine. Ind. J. Pharm. Sci. 70: 619-630, 2008.
19. Venuganti, V., Perumal, O: Effect of Poly(amidoamine) (PAMAM) Dendrimer on Skin Permeation of 5-Fluorouracil. Int. J. Pharm. 361:230-238; 2008.
20. Perumal, O., Inagapolla, R., Kannan, RM., Kannan, S: Surface functionality influences cellular trafficking of dendritic nanomaterials Biomaterials 29:3469-3476, 2008. (Paper cited as ‘Must Read’ in Faculty Biology 1000).
21. Panchagnula, R., Bapurao, T., Raj, YA., Pillai, O..: Mefenamic acid: a new polymorph or crystal defect. Pharm. Technol. (Europe). 18.10 Oct p.41 (6), 2006.
22. Panchagnula, R., Bindra, P., Kumar, N., Dey CS., Pillai, O.: Stability of insulin and its implications on transdermal iontophoretic delivery. Die Pharmazie. 61:1014-1018, 2006.
23. Varma, MVS., Perumal, O., Panchagnula, R.,: Functional Role of P-glycoprotein in limiting peroral drug absorption: optimizing drug delivery. Curr. Opin. Chem. Biol. 10:1-7, 2006.
24. Kolhe, P., Khandare, J., Pillai, O., Kannan, S., Lieh-Lai, M., Kannan, RM.: Design and biological evaluation of dendritic nanodevices for enhanced cellular delivery with a high drug payload. Biomaterials 27:660-669, 2006.
25. Khandare, J., Kolhe, P., Pillai, O. Kannan, S., Lieh-Lai, M., Kannan, RM.: Synthesis, cellular transport and activity of dendrimer-methylprednisolone conjugate. Bioconjugate Chem. 16:330-337, 2005.
26. Kannan, S, Perumal, O., Khandare, Lieh-Lai, M., Kannan, RM., Khandare, J.: Enhanced delivery of anti-inflammatory drugs using novel dendritic nanopolymers. Critical Care Med. 32 (12) suppl: pA142, 2004.
27. Kolhe, P., Khandare, J., Pillai, O., Kannan, S., Lieh-Lai, M., Kannan, RM.: Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery. Pharm. Res. 21: 2185-2195, 2004.
28. Varma, MS., Khandavilli, S., Ashokraj, Y., Jain, A., Dhanikula, A., Sood, A., Thomas, N.S., Pillai, O., Sharma, P., Gandhi, R., Agrawal, S., Nair, V., Panchagnula, R.: Biopharmaceutic classification system: A scientific framework for pharmacokinetic optimization in drug research. Curr. Drug Metabol. 5: 375-388, 2004.
29. Pillai, O., Kumar N., Dey CS., Panchagnula, R.: Transdermal iontophoresis of insulin III: Influence of electronic parameters. Methods Find. Exp. Clin. Pharmacol. 26: 399-408, 2004.
30. Pillai, O., Hamad, M., Crooks, PA, Stinchcomb, AL.: Physicochemical evaluation, in-vitro human skin diffusion and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone. Pharm. Res. 21: 1146-1152, 2004.
31. Agrawal, S., Ashokraj, Y., Bharatam, PV., Pillai, O., Panchagnula, R.: Solid-state characterization of rifampicin samples and its biopharmaceutic relevance. Eur. J. Pharm. Sci. 22: 127-144, 2004.
32. Pillai, O., Panchagnula, R.: Transdermal iontophoresis of insulin VI: Influence of pretreatment with fatty acids on rat skin. Skin Pharmacol. Appl. Skin Phyisol. 17: 289-297, 2004.
33. Panchagnula, R., Prakash, S., Pillai, O., Agrawal, S, Raj, YA.: R. Solid state characterization of mefenamic acid. J. Pharm. Sci. 93: 1019-1029, 2004.
34. Pillai, O., Nair V., Panchagnula, R.: Transdermal iontophoresis of insulin IV: influence of chemical enhancers. Int. J. Pharm. 269: 109-120, 2004.
35. Pillai, O., Kumar N., Dey CS., Borkute, SD., Sivaprasad, N., Panchagnula, R.: Transdermal iontophoresis of insulin I: A study on the issues associated with the use of platinum electrodes. J. Pharm. Pharmacol. 55: 1505-1513, 2003.
36. Pillai, O., Panchagnula, R.: Transdermal delivery of insulin from poloxamer 407 gel: Ex-vivo and in-vivo studies in rat using iontophoresis and chemical enhancers. J. Control. Release 89: 127-140, 2003.
37. Pillai, O., Panchagnula, R.: Transdermal iontophoresis of insulin V: Effect of terpenes. J. Control. Release 88: 287-296, 2003.
38. Pillai, O., Borkute, SD., Sivaprasad, N., Panchagnula, R.: Transdermal Iontophoresis of insulin II: Physicochemical considerations. Int. J. Pharm. 254: 271-280, 2003.
39. Varma, MVS., Pillai, O., Kumar, N., Dey, CS., Panchagnula, R.: Electrochemical stability of insulin under iontophoretic conditions. J. Pharm. Pharmacol. 54: S7, 2002.
40. Gandhi, R., Pillai, O., Thilagavathi, R., Gopalakrishnan, B., Kaul, CL., Panchagnula, R.: Characterization of azithromycin hydrates. Eur. J. Pharm. Sci. 16: 175-184, 2002.
41. Pillai, O., Panchagnula, R.: Insulin therapies- past, present and future. Drug Discov. Today. 20: 1056-1061, 2001.
42. Pillai, O., Nair, V., Jain A., Narisetty ST., Panchagnula, R.: Non-invasive transdermal delivery of peptides and proteins. Drugs Fut. 26: 779-79, 2001
43. Pillai, O., Panchagnula, R.: Polymers in drug delivery. Curr. Opin. Chem. Biol. 5: 447-450, 2001. (Number 5 in top 25 most downloaded articles in this journal).
44. Pillai, O., Dhanikula, AB., Panchagnula, R.: Drug Delivery- an Odyssey of 100 years. Curr. Opin. Chem. Biol. 5: 439-446, 2001.
45. Pillai, O., Nair, V., Borkute, S., Sivaprasad, N., Ramarao, P., Panchagnula, R.: A Modified radioimmuno assay for in vitro analysis of insulin. Ind. J. Nucl. Med. 15: 181-183, 2001.
46. Gandhi, R., Pillai, O., Kaul, CL., Panchagnula, R.: Solid state characterization of azithromycin.
J. Pharm. Pharmacol.52s: 83, 2000.
47. Nair, VB., Pillai, O., Ramarao, P., Panchagnula, R.: Effect of ionic strength on transdermal iontophoresis of arginine vasopressin. J. Pharm. Pharmacol. 52s: 79, 2000.
48. Pillai, O., Nair, VB., Ramarao, P., Panchagnula, R.: Effect of pH and electrode polarity on transdermal iontophoresis of insulin. J. Pharm. Pharmacol. 52s: 92, 2000.
49. Panchagnula, R., Pillai, O., Nair, V., Poduri, R.: Transdermal Iontophoresis revisited. Curr. Opin. Chem. Biol. 4: 468-473, 2000.
50. Panchagnula, R., Jain, AK., Pillai, O., Jaiswal, JK.: Nicotine Transdermal Systems: Pharmaceutical and Clinical aspects. Methods Find. Exp. Clin. Pharmacol. 22: 299-308, 2000.
51. Pillai, O., Nair, VB., Panchagnula, R.: A comparative study of chemical vs iontophoretic enhancement through skin using ATR-FTIR. J. Pharm. Pharmacol 51s: 303, 1999.
52. Pillai, O., Nair, V., Poduri, R., Panchagnula, R.: Transdermal Iontophoresis. Part II. Peptide and Protein delivery. Methods Find. Exp. Clin. Pharmacol. 21: 229-240, 1999.
53. Nair, V, Pillai, O., Poduri, R., Panchagnula, R.: Transdermal Iontophoresis. Part I. Basic Principles and Considerations. Methods Find. Exp. Clin. Pharmacol. 21: 139-151, 1999.

BOOK CHAPTERS
1. Gupta, U., Perumal, O. Dendrimers and its biomedical applications in Natural and synthetic biomedical polymers. Edited by S. Kumbar, C. Laurencin, M. Deng, Elsevier Inc., Amsterdam, First edition, pp. 243-258, 2014.
2. Perumal, O., Haywood, A., Glass, BD., Ho PC. Pharmacokinetics and biopharmaceutics in Multiple Choice Questions in Pharmaceutics. Edited by S. Garg, Pharmaceutical Press, London, UK, pp 41-86, 2011.
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