Office BuildingAvera Health & Science Center
Mailing AddressAvera Health & Science 261
Pharmaceutical Sciences-Box 2202C
Brookings, SD 57007
BiographyDr. Chandrasekher teaches graduate and undergraduate courses for Professional Pharm D and Pharmaceutical Sciences Ph.D students in the areas of Biochemistry, Pathophysiology, and Biomedical Sciences.
His research focus is on mechanisms of cellular signaling in ocular tissues (cornea and lens) in health and disease
EducationPostdoctoral – Lens proteins and cataract, University of Melbourne, Australia; Cornea wound healing, Louisiana State University Health Sciences Center, New Orleans, LA.
Ph.D. – Biochemistry (Protease and amylase inhibitors), Mysore University, India
MS. – Biochemistry, Osmania University, India
BS. – Chemistry (major) and Biology (minor), Andhra University, India
Academic Interests/ExpertiseDr. Chandrasekher's research focus is on inter-cellular interactions, i.e growth factor and extracellular matrix signal cross-talk between different corneal layers for the promotion of cell adhesion, migration and proliferation during corneal epithelial wound healing. Recently, I have initiated studies on developing new therapeutic strategies for diseases related to corneal wounds and dystrophies. This research led to the development of novel extracellular matrix based biomaterial that is being patented.
Growth factors and Extracellular matrix
Cornea and wound healing
Lens and cataract
Pharmaceutical Biochemistry - PHA 323
Pathophysiology, Pharmacology, Toxicology – PHA 352, PHA 353
Advanced Concepts in Biomedical Sciences and Pharmacogenomics – PHA 725
Advanced techniques in Pharmaceutical Sciences – PHA 846
Introduction to Pathophysiology – PHA 320/NURS 323
Advanced concepts in Pharmacology – PHA 840
Independent study - PHA 398
Mentoring graduate students for their Ph.D dissertation.
Mentoring undergraduate student research.
Committee ActivitiesUniversity Senate 2013-2019
University Academic Affairs 2018- to date
College of Pharmacy Curriculum and Progression 2018- to date
Awards and HonorsSession moderator - Corneal Epithelium Wound Repair and Healing - ARVO (Association for Research in Vision and Ophthalmology) meeting, April 28 – May 2, 2019
NIH Grant Reviewer- Study section member for multiple National Eye Institute (NIH/NEI) grant review panels
ETTN G-12 (B), SBIR/STTR Sensory Technologies - June 2013, Feb 2013, November 2012, June 2012, Feb 2012, November 2011, July 2011(editorial reviewer), Feb 2011, June 2010, March 2010, June 2009, October 2009
ETTN-E (52) R, Anterior Eye Diseases-conflict (RO1, R21s) June 2011, June 2010, March 2010, June 2009, October 2009
International visiting scientist fellowship of University of Melbourne, Australia (1988-90)
GrantsNIH RO1 - Growth factor-mediated cell signaling mechanisms in lens 2000-05
South Dakota Board of Regents 2010 center Pilot grant 2013
SDSU Academic Excellence Fund - 2013
SDSU Research Support Fund - 2015, 2017
Saudi Arabia Cultural Mission (SACM), Washington DC, 2013-15
PatentsNovel extracellular matrix-based Biomaterial Composition and Methods for Ocular and other therapeutic
applications (patent pending).
Professional MembershipsMember of Association for Research in Vision and Ophthalmology (ARVO).
Member of American Association for the Advancement of Science.
Area(s) of ResearchDr. Chandrasekher's area of expertise is in cell and molecular biology, more specifically on growth factor- and extra cellular matrix (ECM)- mediated signal transduction mechanisms. His focus is on inter-cellular interactions, i.e growth factor and extracellular matrix signal cross-talk between different corneal layers for the promotion of cell adhesion, migration and proliferation during corneal epithelial wound healing. His current focus is on developing new therapeutic strategies for diseases related to corneal wounds and dystrophies. Recently, his laboratory developed a novel extracellular matrix based biomaterial (patent pending).
Applications of ResearchDevelopment of new therapeutic strategies for diseases related to corneal wounds and dystrophies.
Bioengineering of corneas for transplantation purposes.