Skip to main content

South Dakota State University

Close Search

Diego Diel

Photo of Diego Diel
Title Assistant Professor
Office Building Animal Disease Research & Diagnostic Laboratory
Room Number 118
Mailing Address South Dakota State University
Veterinary & Biomedical Sciences
SAR 118, Box 2175
Brookings, SD 57007
Websites Lab Website

Specialty Area

  • Virology


DVM, 2004, Federal University of Santa Maria, Brazil
MS, 2007, Federal University of Santa Maria, Brazil
PhD, 2010, Federal University of Santa Maria, Brazil

Academic Interests/Expertise

Virus-host interactions and viral pathogenesis
Molecular/recombinant vaccines
Diagnostic virology

Area(s) of Research

My research focuses on the molecular mechanisms underlying virus-host interactions and vaccine development. We study the mechanisms underlying viral immune evasion that contribute to virus virulence and disease pathogenesis. My ultimate goal in studying virus-host interactions is to translate the basic knowledge generated with these studies into improved vaccines and/or vaccine vectores for infectious disease prevention and control.

Creative Activities

Scientific Publications:

1. Maggioli, M.F., Lawson, S., de Lima, M., Joshi, L.R., Faccin, T.C., Bauermann, F.V., Diel, D.G. Adaptive immune responses following Senecavirus A infection in pigs. Journal of Virology. November 2, 2017. pii: JVI.01717-17. doi: 10.1128/JVI.01717-17. [Epub ahead of print]

2. Martins, M., Joshi, L.J., Rodrigues, F.S., Anziliero, D., Frandoloso, R., Kutish, G.F., Rock, D.L., Weiblen, R., Flores, E.F., Diel, D.G. 2017. Immunogenicity of ORFV-based vectors expressing the rabies virus glycoprotein in livestock species. Virology, Nov; 511:229-239. [Epub ahead of print]

3. Khatiwada, S., Delhon, G., Ponnuraj, P., Chaulagain, S., Luo, S., Diel, D.G., Flores, E.F., Rock, D.L. 2017. A novel poxviral virion protein inhibits NF-κB signaling early in infection. PLOS Pathogens, Aug 7;13(8):e1006561. doi: 10.1371/journal.ppat.1006561.

4. Okda, F.A., Lawson, S., Singrey, A., Nelson, J., Hain, K.S., Joshi, L.R., Christopher-Hennings, J., Nelson, E.A., Diel, D.G. 2017. The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing epitopes. Virology, Jun 22;509:185-194. doi:10.1016/j.virol.2017.06.013.

5. Bauermann, F.V., Joshi, L.R., Mohr, K.A., Kutish, G., Meier, P., Chase, C., Christopher-Hennings, J., Diel, D.G. 2017. A novel bovine papillomavirus type in the genus Dyokappapapillomavirus. Archives of Virology, Jun 14. doi: 10.1007/s00705-017-3443-9. [Epub ahead of print]

6. Van Noort, A., Nelsen, A., Pillatzki, A.E., Diel, D.G., Li, F., Nelson, E., Wang, X. Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus-like particles plus 2', 3'-cGAMP VacciGradeTM adjuvant exacerbates viremia after virus challenge. Accepted Virology Journal, March 29, 2017.

7. Joshi, L.R., Fernandes, M.H.V., Clement, T., Lawson, S., Pillatzki, A., Resende, T.P., Vanucci, F.A., Kutish, G.F., Nelson E.A., Diel, D.G. 2016. Pathogenesis of Senecavirus A infection in finishing pigs. Journal of General Virology. Oct 14 doi:10.1099/jgv.0.000631.

8. Hain, K.S., Joshi, L.R., Okda, F., Nelson J., Singrey, A., Lawson, S., Martins, M., Pillatzki, P., Kutish, G.F., Nelson, E.A., Flores, E.F., Diel, D.G. 2016. Immunogenicity of a Recombinant Parapoxvirus Expressing the Spike Protein of Porcine Epidemic Diarrhea Virus. Journal of General Virology. Aug 24. doi: 10.1099/jgv.0.000586.

9. Cardenas-Garcia, S., Dunwoody, R. P., Marcano, V., Diel, D.G., Williams, R. J., Gogal Jr., R. M., Brown, C. C., Miller, P. J., Afonso, C. L. 2016. Effects of Chicken Interferon Gamma on Newcastle Disease Virus Vaccine Immunogenicity. Plos One, Jul 13;11(7):e0159153. doi: 10.1371/journal.pone.0159153.

10. Diel, D.G., Lawson S., Okda F., Singrey, A., Clement T., Fernandes, M.H.V., Christopher-Hennings, J., Nelson, E.A. 2016. Porcine epidemic diarrhea virus: an overview of current virological and serological diagnostic methods. Virus Research, May 14. pii: S0168-1702(16)30209-X. doi: 10.1016/j.virusres.2016.05.013.

11. Burmakina, G., Malogolovkin, A., Tulman, E.R., Zsak, L., Delhon, G., Diel, D.G., Shobogorov, N.M., Morgunov, Y.P., Morgunov, S.Y., Kutish, G.F., Kolbasov, D., Rock, D.L. 2016. African swine fever virus serotype-specific proteins are significant protective antigens for African swine fever. Journal of General Virology, April 25. doi: 10.1099/jgv.0.000490.

12. Joshi, L.R., Mohr, K. A., Clement, T., Hain, K.H., Myers, B., Yaros, Y., Nelson, E.A., Christopher-Hennings, J., Gava, D., Schaefer, R., Caron, L., Dee, S., Diel, D.G. 2016. Detection of the Emerging Picornavirus Senecavirus A in Pigs, Mice and Houseflies. Journal of Clinical Microbiology, June, 54(6):1536-45. doi: 10.1128/JCM.03390-15.

13. Clement, T., Singrey, A., Lawson, S., Okda, F., Nelson, J., Diel, D.G., Nelson, E.A., Christopher-Hennings, J. 2016. Measurement of neutralizing antibodies against porcine epidemic diarrhea virus in sow serum, colostrum, milk and piglet serum after feedback. Journal of Swine Health and Production, 24(3):147-153.

14. Susta, L., Diel, D.G., Courtney, S., Cardenas-Garcia, S., Sundick, R.S., Miller, P.J., Brown, C.C., Afonso, C.L. 2015. Expression of chicken interleukin-2 by a highly virulent strain of Newcastle disease virus leads to decreased systemic viral load but does not significantly affect mortality in chickens. Virology Journal, Aug 8; 12:122. doi: 10.1186/s12985-015-0353-x.

15. Huang, T., Tulman, E.R., Diel, D.G., Khatiwada, S., Sims, W., Edwards, J.F., Wen, X., Kutish, G.F., Rock, D.L., Delhon, G. 2015. Coinfection with multiple strains of bovine papular stomatitis virus. Archives of Virology, Jun, 16, 0(6):1527-32. doi: 10.1007/s00705-015-2394-2.

16. Malogolovkin, A., Burmakina, G., Tulman, E.R., Delhon, G., Diel, D.G., Salnikov, N., Kutish, G. F., Kolbasov, D., Rock, D. L. 2015. African swine fever virus CD2v and C-type lectin gene loci mediate serologic specificity. Journal of General Virology, April, 96(Pt 4):866-73. doi: 10.1099/jgv.0.000024.

17. Cardenas-Garcia, S., Diel, D.G., Susta, L., Yu, Q., Miller, P.J., Brown, C., Afonso, C.L. 2015. Development of an improved vaccine evaluation protocol to compare the efficacy of Newcastle disease vaccines. Biologicals, March, 43(2):136-45. doi:10.1016/j.biologicals. 2014.11.003.

18. Jia, J., Delhon, G., Tulman, E.R., Diel DG, Osorio, F.A., Wen, X., Kutish, G.F., Rock, D.L. 2014. Novel Gammaherpesvirus Functions Encoded by Bovine herpesvirus 6 (Bovine Lymphotropic virus). Journal of General Virology. May 16. pii: vir.0.066951-0. doi: 10.1099/vir.0.066951-0.

19. Susta, L., Cornax, I., Diel, D.G., Garcia, S.C., Miller, P.J., Liu, X., Hu, S., Brown, C.C., Afonso, C.L. 2013. Expression of interferon gamma by a highly virulent strain of Newcastle disease virus decreases its pathogenicity in chickens. Microbial Pathogenesis, 61-62:73-83. doi: 10.1016/j.micpath.2013.05.009.

20. Cornax, I., Diel, D.G., Rue, C.A., Estevez, C., Yu, Q., Miller, P.J., Afonso, C.L. 2013. Newcastle disease virus F and HN proteins contribute to its macrophage host range. Journal of General Virology, 94(Pt 6):1189-94. doi: 10.1099/vir.0.048579-0.

21. Li, J., Hu, H., Yu, Q., Diel, D.G., Li, D-S., Miller, P.J. 2012. Generation and characterization of a recombinant Newcastle disease virus expressing the red fluorescent protein for use in co-infection studies. Virology Journal, 9(1):227.

22. Diel, D.G., da Silva, L.A., Liu, H., Wang, Z., Miller, P.J., Afonso, C.L. 2012. Genetic diversity of avian paramyxovirus type 1: proposal for a unified nomenclature and classification system of Newcastle disease virus genotypes. Infection, Genetics, and Evolution, 12(8):1770-1779.

23. Diel, D.G., Susta, L., Garcia, S.C., Killian, M., Brown, C.C., Miller, P.J., Afonso, C.L. 2012. Complete genome and clinicopathological characterization of a virulent Newcastle disease virus isolate from South America. Journal of Clinical Microbiology, 50(2): 378-387.

24. Diel, D.G., Miller, P.J., Wolf, P.C., Mickley, R.M., Musante, A.R., Emanueli, D.C., Shively, K.J., Pedersen, K., Afonso, C.L. 2012. Characterization of Newcastle disease viruses isolated from cormorant and gull species in the United States in 2010. Avian Diseases, 56, 128-133.

25. Diel, D.G., Luo, S., Delhon, G., Peng, Y., Flores, E.F., Rock, D. 2011. Orf Virus ORFV121 Encodes an Inhibitor of NF-κB that Contributes to Virus Virulence. Journal of Virology, 85(5): 2037- 2049.

26. Diel, D.G., Luo, S., Delhon, G., Peng, Y., Flores, E.F., Rock, D. 2011. A Nuclear Inhibitor of NF-κB encoded by a Poxvirus. Journal of Virology, 85(1): 264-275.

27. Cargnelutti, J.F., Masuda, E.K., Martins, M., Diel, D.G., Rock, D.L., Weiblen, R., Flores, E.F. 2010. Virological and clinic-pathological features of orf virus infection in experimentally infected rabbits and mice. Microbial Pathogenesis, 50(1):56-62.

28. Diel, D.G., Delhon, G., Luo, S., Flores, E.F., Rock, D. 2010. A novel inhibitor of the NF-κB signaling pathway encoded by the parapoxvirus orf virus. Journal of Virology, 84(8): 3962-3973.

29. Henzel, A., Diel D.G., Arenhart, S., Vogel, F.S.F., Weiblen, R. Flores, E.F. 2008. Virological and clinico-pathological features of acute vulvovaginitis and latent infection by bovine herpesvirus 1.2 in heifers experimentally infected. Brazilian Journal of Veterinary Research, 28(3):140-148.

30. Almeida S.R., Diel, D.G., Rissi D.R., Weiblen R. Flores E.F. 2008. Clinic and pathological characterization of acute mammillitis in lactating ewes inoculated with bovine herpesvirus 2. Brazilian Journal of Veterinary Research, 28(1): 87-94.

31. Silva, L.F., Diel, D.G., Cilento, M.C., Weiblen, R., Flores, E.F. 2007. Guinea pigs as a model test of bovine herpesvirus type 1 and bovine viral diarrhea virus inactivated vaccines. Ciencia Rural, 37(4): 1060-1065.

32. Diel, D.G., Almeida, S.R., Brum, M.C.S., Dezengrini, R., Weiblen, R., Flores, E.F. 2007. Acute and latent infection by bovine herpesvirus type 5 in experimentally infected goats. Veterinary Microbiology, 121: 257-267.

33. Diel, D.G., Almeida, S.R., Weiblen, R., Frandoloso, R., Anziliero, D., Kreutz, L.C., Groff, F.H.S., Flores, E.F. 2006. Prevalence of antibodies to influenza virus, viral arteritis and herpesvirus in horses of the state of Rio Grande do Sul, Brazil. Ciencia Rural, 36(5): 1467-1473.

34. Fonseca, E.T. Diel, D.G., Souza, S.F., Mazzanti, A., Weiblen, R., Flores, E.F. 2005. Surgical ablation of the olfactory bulb in rabbits: a model to study the pathogenesis of neurotropic virus infections. Ciencia Rural, 36(2): 544-549.

35. Diel, D.G., Fonseca, E.T., Souza, S.F., Mazzanti, A., Bauermann, F., Weiblen, R., Flores, E.F. 2005. Bovine herpesvirus 5 may use the olfactory and trigeminal pathways to invade the central nervous system of rabbits, depending upon the route of inoculation. Brazilian Journal of Veterinary Research, 25(3):164-170.