Welcome to the RAWC Group
The R. A. Willand-Charnley Group, or better known as the RAWC Lab (pronounced "rock"), performs interdisciplinary research to address the interdisciplinary problems facing society. The work performed in the Willand-Charnley lab spans organic chemistry, chemical biology, glycobiology and cancer immunology. Special emphasis is currently being placed on understanding how various cancers utilize sugar residues and their associated genes to evade the immune system. The information learned is being used to investigate and develop therapeutics.
See our recent working detailing how colon and lung cancers are able to evade immune cell mediated cytotoxicity via the modulation of O-acetylation!
Monoperoxyacetal electrophiles, members of the highly advantageous peroxide functional group, provide a novel route to an important class of reactants, ketene O,O- and N,O-acetals. This cover, created by Christopher Charnley (@ph3_rc), illustrates the synthesis of isolable, heteroaryl ketene acetals through intermolecular etherification of peroxides with lithiated benzofurans, indoles and pyridines.
Take a tour of Avera, where research and learning go hand in hand. Avera Health and Science Center opened in July 2010 and features 97,000 square feet of teaching, laboratory and office space as well as 48,600 square feet of research laboratory space. Home to the College of Pharmacy and Allied Health Professions and the Chemistry Department. Built and equipped at a cost of $50 million with a lead gift of $15 million from Avera Health. Dedicated Sept. 9, 2010, with Julie Gerberding, former CDC director, as speaker.