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Fathi Halaweish Research

Recent Publications

Recent Publications

Estrone derivitization to analogs targeting various cancers

 

  1. Estrone analogs as potential inhibitors targeting EGFR-MAPK pathway in non-small cell lung cancer. Chemical Biology and Drug Design. 2023, 1-11.
    1. Acheampong, F.; Ostlund, T.; Mahnashi, M.; Halaweish, F. 
  2. Novel EGFR-MAPK Kinase and ABC Transporter Inhibitors for HepG2 Resistant to Erlotinib. Drug Discovery Research. 2023, 84, 200-210.
    1. Ostlund, T.; SutraDhar, K.; Elgazwi, S.; Mahnashi, M.; Kyeremateng, J.; Iram, S.; Halaweish, F.
  3. Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer. Steroids 2022, 177, 108950.
    1. Ostlund, T.;  Alotaibi, F.;  Kyeremateng, J.;  Halaweish, H.;  Kasten, A.;  Iram, S.; Halaweish, F.
  4. Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cucurbitacin D Attenuates Pancreatic Cancer). Cells 2020, 9, 103.
    1. M. Sikander, S. Malik, S. Khan, S. Kumari, N. Chauhan, P. Khan, F. T. Halaweish, B. Chauhan, M. M. Yallapu, M. Jaggi, S. C. Chauhan
  5. "Design, synthesis and biological study of hybrid drug candidates of nitric oxide releasing cucurbitacin-inspired estrone analogs for treatment of hepatocellular carcinoma." Bioorganic Chemistry” 85, 515-533, 2019.
    1. Mahrous A. Abou-Salim, Mohamed A. Shaaban, Mohammed K. Abd El Hameid, Yaseen AMM Elshaier, Fathi Halaweish
  6. "Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR–MAPK pathway." European Journal of Medicinal Chemistry 173, 294-304, 2019.
    1. Mater Mahnashi, Sara M. Elgazwi, Mahmoud Salama Ahmed, Fathi T. Halaweish
  7. "Cucurbitacin d reprograms glucose metabolic network in prostate cancer." Cancers 11, 364, 2019.
    1. Mohammed Sikander, Shabnam Malik, Neeraj Chauhan, Parvez Khan, Sonam Kumari, Vivek Kumar Kashyap, Sheema Khan et al
  8. "Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation." BMC complementary and alternative medicine 18, 274-, 2018.
    1. Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Hesham S. M. Soliman, Sivakumar Annadurai, Fathi T. Halaweish
  9. "The role of cucurbitacins in combating cancers: A mechanistic review." Pharmacognosy Reviews, 42,157-165, 2018.
    1. Abdulrhman Alsayari, Fathi Halaweish, Narasimman Gurusamy
  10. Cucurbitacin B Restored Cisplatin Sensitivity of Ovarian Cancer Cells by altering Fatty Acid Synthase and LRP-130 Protein Expression, CPQ Cancer, 1(4) 2018.
    1. F. El-Senduny, F. Badria, A. El-Waseef, S. Chauhan, F. Halaweish
  11. Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells; European Journal of Medicinal Chemistry, 155, 782-796, 2018.
    1. Rania S.M., Wagdy M. Eldehna, Nasser S.M. Ismail, Sara M. Elgazwi, Hazem A. Ghabbour, Mahmoud Salama Ahmed, Fathi T. Halaweish, Dalal A. Abou El Ella
  12. Ormeloxifene Suppresses Prostate Tumor Growth and Metastatic Phenotypes via Inhibition of Oncogenic β-catenin Signaling and EMT Progression; Molecular Cancer Therapeutics, 16, 2267-2280, 2017.
    1. Bilal Bin Hafeez, Aditya Ganju, Mohammed Sikander, Vivek K. Kashyap, Zubair Bin Hafeez, Neeraj Chauhan, Shabnam Malik, Andrew E. Massey, Manish K. Tripathi, Fathi T. Halaweish, Nadeem Zafar, Man M. Singh, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi
  13. Design and synthesis of pyrazolo [3, 4-d] pyrimidines: Nitric oxide releasing compounds targeting hepatocellular carcinoma, Bioorganic and Medicinal Chemistry, 25, 2956-2970, 2017.
    1. Yaseen A. M. M. Elshaier, Mohamed A. Shaaban, Mohammed K. Abd El Hamid, Mostafa H. Abdelrahman, Mahrous A. Abou-Salim, Sara M. Elgazwi, Fathi Halaweish
  14. Biological Screening of Cucurbitacin Inspired Estrone Analogs Targeting Mitogen Activated Protein Kinase (MAPK) Pathway, Chemistry, Biology and Drug Design, 90, 478-484, 2017.
    1. M. S. Ahmed, F. El-Senduny, J. Taylor, F. Halaweish
  15. Mechanistic investigation of hepato-protective potential for cucurbitacins, Med Chem Res 26,1567, 2017.
    1. H. M. Arjaibi, M. S. Ahmed, F. T. Halaweish
  16. Design, Synthesis and Biological Evaluation of Steroidal Analogs as estrogenic / anti-estrogenic agents, Steroids, 118, 32–40, 2017.
    1. A. Alsayari, L. Kopel, M. S. Ahmed, A. Pay, T. Carlson, F. Halaweish
  17. Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer, Scientific Reports, 6, 2016.
    1. M. Sikander, B. Bin Hafeez, S. Malik, A. Alsayari, F. Halaweish, M. Yallapu, C. Subhash, S. Chauhan, M. Jaggi
  18. Assessment of Chemopreventive Contents of Native American Juneberries (Amelanchier alnifolia (Nutt.) Nutt. ex M. Roem.), Pharmaceutical crops,10, 13-21, 2016.
    1. Shimara Gunawardana, Keeli Eberhart, Kerry Hartman1, Fathi T. Halaweish
  19. Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B, Tumor Biology,  37, 685–698, 2016.
    1. F. El-Senduny, F. Badria, A. El-Waseef, S. Chauhan and F. Halaweish
  20. Nanoparticle formulation of ormeloxifene for pancreatic cancer, Biomaterials, 53, 731-743, 2015.
    1. P. Balabathula, A. Swathi, N. Zafar, P. Thompson, R. T. Ellis, F. Halaweish, S. Chauhan, M. Jaggi, Sheem Khan
  21. Cucurbitacin D is a disruptor of the hsp90 chaperone machinery, Journal of Natural Products, J. Nat. Prod., March 10, 2015.
    1. J. Hall, N. Rice, I. Kopel, F. Halaweish, B. Blagg
  22. Ormeloxifene efficiently inhibits ovarian cancer growth, Cancer Letters, 356, 606–612, 2015.
    1. Diane M. Maher, Sheema Khan, Jordan L. Nordquist, Mara C. Ebeling, Nichole A. Bauer, Lucas Kopel, Man Mohan Singh, Fathi Halaweish, Maria C. Bell, Meena Jaggi, Subhash C. Chauhan
  23. Structural Optimization and Biological Screening of a Steroidal Scaffold Possessing Cucurbitacin-Like Functionalities as B-Raf Inhibitors, ChemMedChem, 9, 1361-1369, 2014.
    1. Mahmoud S. Ahmed, Lucas C. Kopel, Fathi Halaweish
  24. Design, Synthesis and In vitro Anti-tumor Evaluation of Novel Acrylohydrazide Thioglycosides; Med. Chem. 4, 400-406, 2014.
    1. Galal H. Elgemeie, Nahed M. Fathy, Ayman B. Farag, Ossama M. El-Badry, Ghaneia S. Hassan, Kamelia M Amin, Fathi Halaweish