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Chemistry and Biochemistry

Eksigent NanoLC-ThermoFisher LTQ Mass Spectrometer System

Picture of Eksigent NanoLC-ThermoFisher LTQ Mass Spectrometer System

About the LTQ 

SpecificationsCommon Applications
  • Mass Range: m/z 150-2,000
  • Resolution (m/Δm): 4,000
  • Accuracy: 100 ppm
  • Ionization Source: Electrospray Ionization (ESI)
  • Mass Analyzer: Linear Ion Trap (LIT)
  • High-speed LCMS
  • Proteomics/metabolomics
  • Structural elucidation
  • Protein identification and quantitative differential expression analysis
  • Biomarker studies and post-translation modification identification
  • Metabolite identification and quantification

Publications Using a LTQ

  • Ai, G.; Dachineni, R.; Kumar, D.; Marimuthu, S.; Alfonso, L.; Bhat, G. Aspirin acetylates wild type and mutant p53 in colon cancer cells: Identification of aspirin acetylated sites on recombinant p53. Tumor Biol. 2016, 37 (5), 6007-6016.
  • Armenta, J.; Perez, M.; Yang, X.; Shapiro, D.; Reed, D.; Tuli, L.; Finkielstein, C.; Lazar, I. Fast proteomic protocol for biomarker fingerprinting in cancerous cells. J. Chromatogr. A. 2010, 1217 (17), 2862-2870.
  • Wu, W.; Wang, G.; Insel, P.; Hsaio, C.; Zou, S.; Maudsley, S.; Martin, B.; Shen, R. Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD). J. Am. Soc. Mass Spectrom.2011, 22 (10), 1753-1762.
  • Cho, Y.; Lee, S.; Ko, Y.; Cho, D.; Lee, H.; Hwang, I.; Nam, H.; Heo, E.; Kim, J.; Jung, S. Definition of purified enzyme-linked immunosorbent assay antigens from culture filtrate protein of Mycobacterium bovis by proteomic analysis. J. Immunoassay Immunochem. 2009, 30 (3), 291-304.
  • Jia, S.; Niu, Z.; Zhang, L.; Zhong, X.; Shi, T.; Du, H.; Zhang, G.; Hu, Y.; Su, X.; Ji, J. Identification of prognosis-related proteins in advanced gastric cancer by mass spectrometry-based comparative proteomics. J. Cancer Res. Clin.2009, 135 (3), 403-411.