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Core Campus Mass Spectrometry Facility

Picture of Dr. Brian Logue

Brian Logue

Interim Coordinator - Core Campus Mass Spectrometry Facility
Phone: 605-688-6698

Department of Chemistry and Biochemistry
Avera Health and Science Center, Room 131
Box 2202
South Dakota State University
Brookings, SD 57007

Core Campus Mass Spectrometry Facility at SDSU

This facility is located in the Avera Health and Science Center as part of the Department of Chemistry and Biochemistry on the laboratory and research side of the building. The equipment is available to university staff and students as well as to the general public for a fee. In order to use the equipment, please contact Brian Logue. He will let you know about availability as well as answer any specific questions.


Instrument/CategorySDSUAcademic-non SDSUIndustry
*MS Facility Personnel Time$100/hr.$150/hr.$300/hr.

*MS Facility Personnel Time encompasses requested activities specific to individual users, including face-to-face training, mobile phase preparation, column preparation, sequence setup, sample preparation, method development consultation and other user-requested services which require MS facility personnel time. This does not include troubleshooting, preventative maintenance, etc.



  • Mass Range: m/z 5-1,250
  • Resolution (m/Δm): 2,000
  • Accuracy: 1 ppm
  • Scan Speed: 20,000 Da/s
  • Polarity switching in 50 ms
  • Ionization Source: Electrospray Ionization
  • Mass Analyzer: Triple Quadrupole

Common Applications

  • Fast LC/MS
  • Metabolite Identification
  • Detection and confirmation of low level pesticides
  • Protein/peptide quantitation for biomarker verification and validation
  • Ultra-fast and selective MRM scans mean you can target and quantify thousands of compounds in a single analysis


  • Mass Range: m/z 500-1,000,000
  • Resolution (m/Δm): 5,000 (linear mode), 20,000 (reflectron mode)
  • Accuracy: 200 ppm (linear mode), 10 ppm (reflectron mode)
  • 337 nm Laser
  • Ionization Source: Matrix-assisted laser desorption ionization (MALDI)
  • Mass Analyzer: Time of flight (TOF)

Common Applications

  • Characterization of biopolymers (proteins, protein digests and oligonucleotides)
  • Organometallic complexes
  • Some synthetic polymers
  • Molecules that photoionize upon radiation by 337 nm laser
  • Labile molecules


  • Mass Range: m/z 150-2,000
  • Resolution (m/Δm): 4,000
  • Accuracy: 100 ppm
  • Ionization Source: Electrospray Ionization (ESI)
  • Mass Analyzer: Linear Ion Trap

Common Applications

  • High-speed LCMS
  • Proteomics/metabolomics
  • Structural elucidation
  • Protein identification and quantitative differential expression analysis
  • Biomarker studies and post-translation modification identification
  • Metabolite identification and quantification

Advisory Committee