Nutraceutical is a “food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease.”
Objective A- Development of Digestive Health Improving Nutraceuticals
•Minibioreactor (in vitro test)
•100 strains screened from 2000 isolates
•576 Prebiotic –probiotic blends to be tested
•Encapsulation
•Freeze drying
•Stability
•Scale up
•Humanized pig model (in vivo test)
•Determine dose & safety
•Clinical trial
•Recruit participants through Sanford Profile clinics
•Nutraceutical
•Licensing
•Private label product
B- Development of direct fed microbials to improve swine health
•Minibioreactor (in vitro test)
•50 blends screened from 1000 isolates
•Production of beneficial metabolites & effect on microbiome
•Encapsulation
•Freeze drying
•Stability
•Scale up
•Pilot study(in vivo test)
•Determine dose & safety
•Digestive health & effect on gut microbiome
•Farm trial
•Real life testing in Purina farm
•Digestive health & effect on gut microbiome
•Direct fed microbial
•Licensing
•Private label product
Objective C- Develop gut bacterial blends to treat drug resistant infections
•Minibioreactor (in vitro test)
•Develop blends to suppress Clostridium difficile
•Develop blends to suppress Salmonella enterica
•Encapsulation
•Freeze drying
•Stability
•Scale up
•Pilot study(in vivo test)
•Determine dose &safety
•Efficacy to inhibit Salmonella and C. difficile
•Clinical trial
•Safety
•Efficacy to inhibit Salmonella and C. difficile
•Pathogen suppressing blend
•Marketing/ Licensing