My research is primarily focused on the development of novel vaccination strategies against viral pathogens that pose a significant risk to human or animal health. Porcine epidemic diarrhea (PED) is caused by a coronavirus that was first identified in the U.S. in May 2013. Since then, the virus has spread to hog farms in 31 U.S. states and resulted in the deaths of more than 9 million piglets, or more than 10% of U.S. herd.
To prevent the hit from reoccurring, my research group is developing a novel biological nanoparticle PED vaccine with a funding support from USDA/NIFA. The other major component of my research is to study antibody-mediated protection mechanisms against influenza through collaboration with the BioSNTR of South Dakota.
Additional research interests include the mechanistic investigations of virus-host interactions toward the identification of potential targets for antiviral therapy; the roles of influenza virus defective RNA genomes; and the impact of obesity on the effectiveness of mainstream viral vaccine.