Biology & Microbiology
Biology & Microbiology-Box 2140D
Brookings, SD 57007
Areas of Study/Academic Interests:
Viral pathogenesis and viral immunology
Ph.D. (Virology). University of Connecticut, Storrs, CT, USA. 2000. M.S. (Veterinary Pathology). Inner Mongolia College of Agriculture and Animal Husbandry, Huhhot, P. R. China. 1991. D.V.M., Inner Mongolia College of Agriculture and Animal Husbandry, Huhhot, P. R. China. 1988.
Micr424/524, Vet424/524 Medical and Veterinary Virology Bios790 Graduate Seminar, Bios662 Advanced Molecular and Cellular Biology, Bios663 Advanced topics in infectious disease
molecular mechanisms of viral pathogenesis and viral immunity
American Society for Virology
1) South Dakota State EPSCoR CAREER (NSF) May 1, 2003 – October 30, 2004 Title: Molecular Regulation of Mucosal Immunity Total: $ 75,000 Role: PI Goal: To understand the molecular control of mucosal immunity using DNA microarray and real-time PCR techniques. 2) USDA NRI January 15, 2004 –January 14, 2007 Title: Role of dendritic cells in PRRSV pathogenesis Total: $ 74,697 Indirect Cost Recovery Rate: 22.5-23 % Role: PI Goal: To examine the interaction between PRRSV and monocyte-derived DC in vitro and to understand the role of DC in PRRSV pathogenesis. 3) NIH-NIAID April 1, 2004 - March 31, 2008 Title: Murine Cytomegalovirus As a Potent Antigen Delivery Vector Total: $ 141, 262 Indirect Cost Recovery Rate: 42.5-43% Role: PI Goal: To examine the persistence and immunomodulating effects of MCMV on human immune cells. 4) National Pork Board September 15, 2004 – December 15, 2005 Title: A novel herpesvirus vector approach for PRRSV vaccines. Total: $ 25,000. Role: PI Goal: To explore the potential use of a herpes simplex virus based vector approach for PRRSV vaccine development. 5) SD Governor’s 2010 Initiative Research Centers Program Oct. 2004 to June 2006. Title: Improved diagnostic and vaccination strategies for porcine reproductive and respiratory syndrome virus. Total: $100,000 Role: PI Goal: To develop novel strategies for the control and prevention of PRRSV in the US. 6) National Science Foundation (NSF)- MRI Aug. 2005- July 2006 Title: Acquisition of a scanning electron microscope for research purposes Total: $ 252,000 Role: Co-investigator (PI: David Gallipau) 7) NIH-NCI April 2006-Mar. 2009 Title: Inhibition of glutathione reductase and ovarian cancer drug resistance reversal Total: $ 213,000 Role: Co-Investigator, 5% effort (PI: Xiangming Guan) 8) USDA-NRI August 2007-July 2008 Title: Acquisition of the BioPlex Suspension Array System for Multiplex Assay Development in Swine Research Total: $ 28,000 Role: Co-Investigator (PI: Jane Christopher-Hennings) 9) SD AES October 2007- September 2009 Title: Optimization of dendritic cell enrichment procedures to define the coordinated role of dendritic cells and macrophages in PRRSV infection Total: $ 20,000 Role: PI 10) USDA NRI December2008-November 2010 Title: Interaction between PRRSV and interferon alpha/beta induction signaling pathways Total: $ 100,000 Role: PI
Hanmo Zhang, Xiuqing Wang. 2010. A dual effect of PRRSV replication on the PI3K dependent Akt pathway. Archives of Virology. 155:571-575. Sankhiros Babapoor, Davi de Oliveira Almeida, Jaroslaw J. Fabis, Zeinab H. Helal, Xiuqing Wang, Theodore Girshick and Mazhar I. Khan. 2009. Protective Effect of In ovo Vaccination with IBV-Spike-Recombinant DNA and Chicken Interferon as an Adjuvant. International Journal of Poultry Science. Accepted. Xiuqing Wang, Daphne Moutsoglou. 2009. Osteogenic and adipogenic differentiation potential of an immortalized fibroblast-like cell line derived from pig peripheral blood. In Vitro Cellular & Developmental Biology - Animal. 45(10): 584-591. Xiuqing Wang, Ding-geng Chen. 2009. Recombinant Murine Cytomegalovirus Vector Activates Human Monocyte-derived Dendritic Cells in a NF-kB Dependent Pathway. Molecular Immunology. 46: 3462-3465. Yong Zhao, Teresa Seefeldt, Wei Chen, Xiuqing Wang, Duane Matthees, Yueshan Hu, and Xiangming Guan. 2009. Effects of Glutathione Reductase Inhibition on Cellular Thiol Redox State and Related Systems. Archives of Biochemistry and Biophysics. 485(1): 56-62. Yuehuan Liu, Chunhua Han, Xiuqing Wang, Jian Lin, Ming Ma, Yuelong Shu, Jiao Zhou, Hanchun Yang, Qian Liang, Chaotan Guo, Junjie Zhu, Haitao Wei, Jingyi Zhao, Jie Pan 2009. Influenza virus receptors in pigeon’s respiratory and intestinal tracts. Avian Pathology. 38 (4): 263-266. Xueshui Guo, Artur J.M. Rosa, Ding-geng Chen, Xiuqing Wang. 2008. Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system. Vet. Immunol. & Immunopathology. 121 (3-4): 332-343. Yuehuan Liu, Jiao Zhou, Hanchun Yang, Weiguang Yao, Weidong Bu, Bing Yang, Weiping Song, Yanni Meng, Jian Lin, Chunhua Han, Zhu Junjie, Ma Zhijun, Zhao Jingyi, Xiuqing Wang. 2007. Susceptibility and transmissibility of pigeons to Asian lineage avian influenza virus H5N1. Avian Pathology. 36(6): 461-465. Xiuqing Wang, Michael Eaton, Malissa Mayer, Hongmei Li, Dong He, Eric Nelson, Jane Christopher-Hennings. 2007. Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch. Virol. 152 (2): 289-303. Xiuqing Wang, Artur J.M. Rosa, Henrique N. Oliverira, Guilherme J.M. Rosa, Xueshui Guo, Mark Travnicek, Theodore Girshick. 2006. Transcriptome of local Innate and Adaptive Immunity During Early Phase of Infectious Bronchitis Virus Infection. Viral Immunol. 19 (4): 768-74. Xiuqing Wang, Messerle, M., Sapinoro, R., Santos, K., Hocknell, P. K., Jin, X., Dewhurst, S. 2003. Murine cytomegalovirus abortively infects human dendritic cells (DC), leading to expression and presentation of virally-vectored genes. J. Virol. 77: 7182-7192. Xiuqing Wang, Rebecca D. Wiley, Thomas G. Evans, William J. Bowers, Howard J. Federoff, Stephen Dewhurst. 2003. DNA priming results in enhanced cellular immune responses following immunization with helper-free HSV-1 amplicon particles encoding HIV-1 gp120. Vaccine 21: 2288-2297. Xiuqing Wang, William M. Schnitzlein, Deoki N.Tripathy, Theodore Girshick, Mazhar I. Khan. 2002. Construction and immunogenicity studies of recombinant fowl poxvirus containing the S1 gene of Massachusetts 41 strain of infectious bronchitis virus. Avian Dis. 2002 46(4):831-8. Hocknell PK, Wiley RW, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst, S. 2002. Expression of human immunodeficiency virus-1 gp120 from herpes simplex virus-1 derived amplicons results in potent, specific and durable cellular and humoral immune responses. J. Virol. 76:5565-5580. Skrincosky D, Willis RA, Hocknell PK, Frelinger JG, Mirandola P, Wang X, Dewhurst S. 2001. Epitope mapping of human herpesvirus-7 gp65 using monoclonal antibodies. Arch. Virol. 146:1705-1722. Xiuqing Wang & Mazhar I. Khan. 2000. Molecular characterization of an infectious bronchitis virus strain isolated from outbreaks in vaccinated layers. Avian diseases. 44: 1000-6. Xiuqing Wang & Mazhar I. Khan. 2000. Use of RT-PCR-RFLP to examine the interaction between IBV strains Massachusetts 41 and JMK in ovo. Avian Pathology. 29: 441-448. Xiuqing Wang & Mazhar I. Khan. 1999. Use of multiplex PCR for the diagnosis of Massachusetts and Arkansas serotypes of infectious bronchitis virus. Molecular and Cellular Probes. 13: 1-7.
Awards & Honors:
Dean's Team Award, SDSU